Publikation:
ERGO: Breaking down the wall between human health and environmental testing of endocrine disrupters

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dc.contributor.authorHolbech, Henrik
dc.contributor.authorArning, Jürgen
dc.contributor.authorMatthiessen, Peter
dc.contributor.authorHansen, Martin
dc.date.accessioned2024-06-16T13:56:18Z
dc.date.available2024-06-16T13:56:18Z
dc.date.issued2020
dc.description.abstractERGO (EndocRine Guideline Optimization) is the acronym of a European Union-funded research and innovation action, that aims to break down the wall between mammalian and non-mammalian vertebrate regulatory testing of endocrine disruptors (EDs), by identifying, developing and aligning thyroid-related biomarkers and endpoints (B/E) for the linkage of effects between vertebrate classes. To achieve this, an adverse outcome pathway (AOP) network covering various modes of thyroid hormone disruption (THD) in multiple vertebrate classes will be developed. The AOP development will be based on existing and new data from in vitro and in vivo experiments with fish, amphibians and mammals, using a battery of different THDs. This will provide the scientifically plausible and evidence-based foundation for the selection of B/E and assays in lower vertebrates, predictive of human health outcomes. These assays will be prioritized for validation at OECD (Organization for Economic Cooperation and Development) level. ERGO will re-think ED testing strategies from in silico methods to in vivo testing and develop, optimize and validate existing in vivo and early life-stage OECD guidelines, as well as new in vitro protocols for THD. This strategy will reduce requirements for animal testing by preventing duplication of testing in mammals and non-mammalian vertebrates and increase the screening capacity to enable more chemicals to be tested for ED properties. © 2020 by the authorsen
dc.format.extent1 Onlineresource (18 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-977
dc.identifier.urihttps://openumwelt.de/handle/123456789/3914
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectEndokrine Wirkung
dc.subjectOECD
dc.subjectInterspeziesextrapolation
dc.titleERGO: Breaking down the wall between human health and environmental testing of endocrine disrupters
dc.title.alternativeBreaking down the wall between human health and environmental testing of endocrine disrupters
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational journal of molecular sciences
local.bibliographicCitation.originalDOI10.3390/ijms21082954
local.bibliographicCitation.volume21 (2020), Heft 8
local.collectionAufsätze
local.contributor.authorId02180800
local.contributor.authorId(DE-588)1068851953
local.contributor.authorId00286517
local.contributor.authorId02159725
local.identifier.catalogId02479884
local.ingest.leader05507naa a2200000uu 4500
local.jointTitleERGO BREAKING DOWN THE WALL BETWEEN HUMAN HEALTH AND ENVIRONMENTAL TESTING OF ENDOCRINE DISRUPTERS
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