Publikation:
The methylisothiazolinone and methylchloroisothiazolinone metabolite N-methylmalonamic acid (NMMA) in urine of children and adolescents in Germany - Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)

Kurzanzeige
dc.contributor.authorConrad, André
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorMurawski, Aline
dc.contributor.authorRucic, Enrico
dc.contributor.authorSchmied-Tobies, Maria Irene Hilde
dc.date.accessioned2024-06-16T14:17:58Z
dc.date.available2024-06-16T14:17:58Z
dc.date.issued2020
dc.description.abstractMixtures of methylisothiazolinone and methylchloroisothiazolinone are used as biocides in cosmetics, cleaning agents, and water-based paint. A biomonitoring method to evaluate exposure to these compounds was developed using N-methylmalonamic acid (NMMA), the main metabolite of both, methylisothiazolinone and methylchloroisothiazolinone, as the exposure biomarker. First-morning void urine samples (N = 2078) of 3- to 17-year-old children and adolescents living in Germany were analysed for concentrations of NMMA in the population representative German Environmental Survey for Children and Adolescents GerES V (2014-2017). NMMA was quantified in almost all samples, with a geometric mean concentration of 6.245 My g/L (5.303 my g/gcrea) and a 95th percentile of 15.0 my g/L (12.6 ÎÌg/gcrea). Urinary concentrations could not be related to self-reported application of specific cleaning agents or personal care products, leaving potential, specific sources of exposure unrevealed as most products relevant for isothiazolinone exposure are used ubiquitously. For the first time, reference values can be derived for urinary NMMA for children and adolescents in Germany, facilitating a more substantiated exposure assessment. © 2020 Published by Elsevier GmbH.en
dc.format.extent1 Onlineressource (6 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-938
dc.identifier.urihttps://openumwelt.de/handle/123456789/4466
dc.language.isoger
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.titleThe methylisothiazolinone and methylchloroisothiazolinone metabolite N-methylmalonamic acid (NMMA) in urine of children and adolescents in Germany - Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)
dc.title.alternativeThe methylisothiazolinone and methylchloroisothiazolinone metabolite N-methylmalonamic acid (NMMA) in urine of children and adolescents in Germany - Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2020.113511
local.bibliographicCitation.volume227 (2020)
local.collectionAufsätze
local.contributor.authorId(DE-588)1164813641
local.contributor.authorId(DE-588)1125139706
local.identifier.catalogId02474703
local.ingest.leader05358naa a2200000uu 4500
local.jointTitleTHE METHYLISOTHIAZOLINONE AND METHYLCHLOROISOTHIAZOLINONE METABOLITE NMETHYLMALONAMIC ACID NMMA IN URINE OF CHILDREN AND ADOLESCENTS IN GERMANY HUMAN BIOMONITORING RESULTS OF THE GERMAN ENVIRONMENTAL SURVEY 20142017 GERES V
local.sourcecatalog
local.staffPublicationtrue
relation.isAuthorOfPublicationbb0eb320-1a69-4eb7-8a9a-2be778f049d7
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublication1cf84dc6-c2cf-42ad-a5a7-f540c343a6e7
relation.isAuthorOfPublication45fcaec1-fa8f-497c-baed-4384fd6c9e91
relation.isAuthorOfPublication145c9bab-4564-4392-99a4-8d8ec7b49a2e
relation.isAuthorOfPublication.latestForDiscoverybb0eb320-1a69-4eb7-8a9a-2be778f049d7
Dateien
Sammlungen
Aufsätze