Publikation:
Bisphenol A: contested science, divergent safety evaluations

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dc.contributor.authorGies, Andreas
dc.contributor.authorSoto, Ana M.
dc.date.accessioned2024-06-16T16:37:38Z
dc.date.available2024-06-16T16:37:38Z
dc.date.issued2013
dc.description.abstractBisphenol A (BPA) is currently one of the world's best-selling chemicals and primarily used<BR>to make polycarbonate plastics. It is widely used in common products such as baby bottles,<BR>household electronics, medical devices and coatings on food containers. BPA is known to mimic<BR>the female hormone oestrogen and has been found to leach from the materials where it is used.<BR>Studies have suggested that even exposure to low doses of BPA may cause endocrine<BR>disrupting effects. As with other hormones, it appears that an organism is most sensitive during<BR>development but that effects are often not observed until much later in the lifecycle. This means<BR>that at the time when the effects become detectable, the chemical exposure has vanished. This<BR>makes it extremely difficult to link exposure to effects in humans.<BR>This chapter maps some of the findings in studies of rodents and humans. It also discusses<BR>the challenges of evaluating scientific findings in a field where industry-sponsored studies and<BR>independent scientific research seem to deviate strongly. The authors offer suggestions for ways<BR>to uncouple financial interests from scientific research and testing.<BR>A widely used and dispersed industrial chemical like Bisphenol A is a controversial example of<BR>an endocrine disrupting substance that has implications for policymakers. Different approaches<BR>to risk assessment for BPA by US and European authorities are presented. It throws light on the<BR>ways in which similar evidence is evaluated differently in different risk assessments and presents<BR>challenges for applying the precautionary principle.<BR>The intense discussion and scientific work on BPA have slowly contributed to a process of<BR>improving test strategies. While traditional toxicology has relied on a monotonic increasing doseresponse<BR>relationship as evidence that the effect is caused by the test agent, studies on BPA and<BR>other endocrine disruptor chemicals (EDCs) have demonstrated the limitations of this approach<BR>and adjustments have been made in some cases.<BR>It has also been widely accepted that effects cannot be predicted by simply thinking of BPA<BR>as a weak oestrogen and extrapolating from what is observed for more potent endogenous<BR>oestrogens. This lesson is particularly evident in the intense pharmaceutical interest in selective<BR>oestrogen response modifiers (SERMs).<BR>The chapter is followed by a panel analysing the value of animal testing for identifyingcarcinogens<BR>Quelle: Late lessons from early warnings: science, precaution, innovation / Part A - Lessons<BR> from health hazards/ Chapter 10en
dc.identifier.doihttps://doi.org/10.60810/openumwelt-898
dc.identifier.urihttps://openumwelt.de/handle/123456789/9338
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleBisphenol A: contested science, divergent safety evaluations
dc.typeTeil eines Buches
dspace.entity.typePublication
local.bibliographicCitation.journalTitleLate lessons from early warnings
local.bibliographicCitation.originalDOI10.2800/70069
local.bibliographicCitation.volume(2013), Seite 247-271
local.collectionAufsätze
local.contributor.authorId00302652
local.identifier.catalogId02384784
local.ingest.leader05494naa a2200000uu 4500
local.jointTitleBISPHENOL A CONTESTED SCIENCE DIVERGENT SAFETY EVALUATIONS
local.sourcecatalog
local.source.urihttp://www.eea.europa.eu/publications/late-lessons-2/late-lessons-chapters/late-lessons-ii-chapter-10
local.staffPublicationtrue
relation.isAuthorOfPublication2242b1f2-47c9-4033-9309-bdb084c6e72b
relation.isAuthorOfPublication.latestForDiscovery2242b1f2-47c9-4033-9309-bdb084c6e72b
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