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The European Human Biomonitoring Initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) for the aprotic solvents N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP)

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dc.contributor.authorApel, Petra
dc.contributor.authorGerofke, Antje
dc.contributor.authorDavid, Madlen
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorLange, Rosa
dc.date.accessioned2024-06-16T13:31:18Z
dc.date.available2024-06-16T13:31:18Z
dc.date.issued2021
dc.description.abstractToxicologically and/or epidemiologically derived guidance values referring to the internal exposure of humans are a prerequisite for an easy to use health-based interpretation of human biomonitoring (HBM) results. The European Joint Programme HBM4EU derives such values, named human biomonitoring guidance values (HBM-GVs), for priority substances which could be of regulatory relevance for policy makers and have been identified by experts of the participating countries, ministries, agencies and stakeholders at EU and national level. NMP and NEP are such substances for which unresolved policy relevant issues should be clarified by targeted research. Since widespread exposure of the general population in Germany to NMP and NEP was shown for the age groups 3-17 years and 20-29 years, further investigations on exposure to NMP and NEP in other European countries are warranted. The HBM-GVs derived for both solvents focus on developmental toxicity as decisive endpoint. They amount for the sum of the two specific urinary NMP metabolites 5-HNMP and 2-HMSI and likewise of the two specific urinary NEP metabolites 5-HNEP and 2-HESI to 10 mg/L for children and 15 mg/L for adolescents/adults. The values were determined following a consultation process on the value proposals within HBM4EU. A health-based risk assessment was performed using the newly derived HBM-GVGenPop and exposure data from two recent studies from Germany. The risk assessment revealed that even when considering the combined exposure to both substances by applying the Hazard Index approach, the measured concentrations are below the HBM-GVGenPop in all cases investigated (i.e., children, adolescents and young adults). © 2021 The Authors. Published by Elsevier GmbH.en
dc.format.extent1 Onlineressource (8 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-888
dc.identifier.urihttps://openumwelt.de/handle/123456789/3224
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectEpidemiologie
dc.subjectForschungspolitik
dc.subjectGesundheit
dc.subjectHuman-Biomonitoring
dc.subjectRisikoanalyse
dc.subjectStoffwechselprodukt
dc.subjectToxizität
dc.titleThe European Human Biomonitoring Initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) for the aprotic solvents N-methyl-2-pyrrolidone (NMP) and N-ethyl-2-pyrrolidone (NEP)
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2021.113856
local.bibliographicCitation.volume238 (2021)
local.collectionAufsätze
local.contributor.authorId02188720
local.contributor.authorId(DE-588)130293997
local.identifier.catalogId02487079
local.ingest.leader06636naa a2200000uu 4500
local.jointTitleTHE EUROPEAN HUMAN BIOMONITORING INITIATIVE HBM4EU HUMAN BIOMONITORING GUIDANCE VALUES HBMGVS FOR THE APROTIC SOLVENTS NMETHYL2PYRROLIDONE NMP AND NETHYL2PYRROLIDONE NEP
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