Publikation:
Human biomonitoring reference values: Differences and similarities between approaches for identifying unusually high exposure of pollutants in humans

Kurzanzeige
dc.contributor.authorApel, Petra
dc.contributor.authorConrad, André
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorRucic, Enrico
dc.contributor.authorVogel, Nina
dc.date.accessioned2024-06-16T15:01:10Z
dc.date.available2024-06-16T15:01:10Z
dc.date.issued2019
dc.description.abstractIn exposure and risk assessment, the indication of unusually high exposure levels in humans to chemicals has been considered as an important objective for decades. To realize this objective, reference values (RV) need to be derived. However, while there is a tendency towards using the 95th percentile as a basis for deriving these reference values there is still no consensus. Moreover, side approaches have evolved including deriving RVs based on other percentiles, reporting multiple RVs or only reporting percentiles. The purpose of this article is to give an overview of the current literature, to point out differences and similarities between existing approaches, and to highlight important criteria for the derivation of RVs. We observe the majority of studies to base RVs on the 95th percentile and its 95% confidence interval which can been justified by statistical paradigms, present arguments for a single defined reference value, and discuss characteristics which call for more consistency. To conclude, our overview provides a first step towards a more homogenous and standardized derivation procedure to identify unusually high exposures in exposure science. © 2018 The Authors. Published by Elsevier GmbH.en
dc.format.extent1 Onlineressource
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-850
dc.identifier.urihttps://openumwelt.de/handle/123456789/5832
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectReferenzwert
dc.subjectHuman-Biomonitoring
dc.titleHuman biomonitoring reference values: Differences and similarities between approaches for identifying unusually high exposure of pollutants in humans
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2018.08.002
local.bibliographicCitation.volume222 (2019), Heft 1, Pages 30-33
local.collectionAufsätze
local.contributor.authorId(DE-588)137690304
local.identifier.catalogId02462157
local.ingest.leader05146naa a2200000uu 4500
local.jointTitleHUMAN BIOMONITORING REFERENCE VALUES DIFFERENCES AND SIMILARITIES BETWEEN APPROACHES FOR IDENTIFYING UNUSUALLY HIGH EXPOSURE OF POLLUTANTS IN HUMANS
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