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Publikationstyp
Wissenschaftlicher Artikel
Erscheinungsjahr
2013
Tox-Box
Tox-Box
securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany
Autor:innen
Herausgeber
Quelle
Environmental Sciences Europe
25 (2013)
25 (2013)
Schlagwörter
Forschungskennzahl (FKZ)
Verbundene Publikation
Zitation
Tox-Box, 2013. Environmental Sciences Europe [online]. Bd. 25 (2013). DOI 10.60810/openumwelt-775. Verfügbar unter: https://openumwelt.de/handle/123456789/9184
Zusammenfassung englisch
This article introduces ´Tox-Box, a joint research project designed to develop a holistic approach towards a harmonized testing strategy for exposure- and hazard-based risk management of anthropogenic trace substances in drinking water to secure a long-term drinking water supply. The main task of the Tox-Box consortium is to enhance the existing health-related indicator value concept (German: GOW-Konzept - Gesundheitlicher Orientierungswert) through development and prioritization of additional end point-related testing strategies for genotoxicity, neurotoxicity, germ cell damage, and endocrine effects. In this context, substance-specific modes of action will be identified and characterized. Toxicological data collected by the 12 Tox-Box subprojects will be evaluated and weighted to structure a hierarchical testing strategy for an improved risk assessment. A technical guidance document for exposure and hazard-based risk management of anthropogenic trace substances in drinking water will eventually be prepared.
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