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Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the "European Human Biomonitoring Initiative" HBM4EU participating studies

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dc.contributor.authorFernández, Sandra
dc.contributor.authorPoteser, Michael
dc.contributor.authorGovarts, Eva
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorMurawski, Aline
dc.contributor.authorRüther, Maria
dc.contributor.authorSchmidt, Phillipp
dc.contributor.authorVogel, Nina
dc.contributor.authorWeber, Till
dc.date.accessioned2024-06-16T12:34:14Z
dc.date.available2024-06-16T12:34:14Z
dc.date.issued2023
dc.description.abstractLittle is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014-2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3-18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20-45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences ((beta) coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA ((micro)g/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA: (beta) = -9.1 (micro)g/g creatinine, 95% CI -15.8, -2.4; GAMA: (beta) = -3.4 (micro)g/g creatinine, 95% CI-4.7, - 2.2), living in rural areas (AAMA: (beta) = - 4.7 (micro)g/g creatinine, 95% CI - 8.6, - 0.8; GAMA: (beta) = - 1.1 (micro)g/g creatinine, 95% CI -1.9, -0.4) and increasing age (AAMA: (beta)= -1.9 (micro)g/g creatinine, 95% CI -2.4, -1.4; GAMA: (beta) = -0.7 (micro)g/g creatinine, 95% CI -0.8, -0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries. © The Author(s) 2023en
dc.format.extent1 Online-Resource (11 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-741
dc.identifier.urihttps://openumwelt.de/handle/123456789/1302
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleDeterminants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the "European Human Biomonitoring Initiative" HBM4EU participating studies
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleScientific reports
local.bibliographicCitation.originalDOI10.1038/s41598-023-48738-6
local.bibliographicCitation.volume13 (2023), Heft 1
local.collectionAufsätze
local.contributor.authorId02193430
local.contributor.authorId02190211
local.contributor.authorId02160044
local.identifier.catalogId02502617
local.ingest.leader06483naa a2200000uu 4500
local.jointTitleDETERMINANTS OF EXPOSURE TO ACRYLAMIDE IN EUROPEAN CHILDREN AND ADULTS BASED ON URINARY BIOMARKERS RESULTS FROM THE EUROPEAN HUMAN BIOMONITORING INITIATIVE HBM4EU PARTICIPATING STUDIES
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local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
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