Publikation:
New insights on in vitro biotransformation of anticoagulant rodenticides in fish

Kurzanzeige
dc.contributor.authorRegnery, Julia
dc.contributor.authorFriesen, Anton
dc.contributor.authorRiegraf, Carolin
dc.contributor.authorJacob, Stefanie
dc.date.accessioned2024-06-16T12:49:45Z
dc.date.available2024-06-16T12:49:45Z
dc.date.issued2022
dc.description.abstracthe assessment of the bioaccumulation potential of chemicals is an essential and mandatory part of their regulatory environmental risk and hazard assessment. So far, in vitro data on fish metabolism is rarely available for biocidal active substances such as anticoagulant rodenticides. In this case study we present in vitro biotransformation rates of eight biocidal and one pharmaceutical anticoagulants in rainbow trout (Oncorhynchus mykiss) liver subcellular S9 fraction (RT-S9) determined following the Organisation for Economic Co-operation and Development test guideline 319B method at two different incubation temperatures (i.e., 12 +/- 1 ËÌC and 23 +/- 2 ËÌC). Furthermore, we address challenges associated with the usability and interpretation of in vitro data to support the decision making within the regulatory bioaccumulation assessment in bridging the gap between in silico methods and in vivo studies. According to our results, four of the tested substances (i.e., chlorophacinone, coumatetralyl, bromadiolone, and difenacoum) exhibited significant intrinsic clearance (p < .001) in the RT-S9 assay. Overall, the observed metabolism was (very) slow and clearance rates were temperature-dependent. Whether the determined in vitro biotransformation rate had a substantial influence on the predicted bioconcentration factor during extrapolation was subject to the lipophilicity of the test substance. Further improvements of existing concepts are needed to overcome uncertainties in the prediction of bioconcentration factors for chemicals such as anticoagulants. © 2022 Elsevier Ltd.en
dc.format.extent1 Online-Ressource (9 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-712
dc.identifier.urihttps://openumwelt.de/handle/123456789/1908
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBioakkumulation
dc.titleNew insights on in vitro biotransformation of anticoagulant rodenticides in fish
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleChemosphere
local.bibliographicCitation.originalDOI10.1016/j.chemosphere.2022.133727
local.bibliographicCitation.volume294 (2022)
local.collectionAufsätze
local.contributor.authorId02181660
local.contributor.authorId(DE-588)142337552
local.contributor.authorId02179309
local.identifier.catalogId02498557
local.ingest.leader05099naa a2200000uu 4500
local.jointTitleNEW INSIGHTS ON IN VITRO BIOTRANSFORMATION OF ANTICOAGULANT RODENTICIDES IN FISH
local.reviewtrue
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relation.isAuthorOfPublication.latestForDiscoveryfea5c8e7-f6e9-46b5-b70a-e1e15a30fdb0
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