Publikation:
Human Biomonitoring in urine samples from the Environmental Specimen Bank reveals a decreasing trend over time in the exposure to the fragrance chemical lysmeral from 2000 to 2018

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dc.contributor.authorScherer, Max
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorPetreanu, Wolf
dc.contributor.authorWeber, Till
dc.date.accessioned2024-06-16T13:59:47Z
dc.date.available2024-06-16T13:59:47Z
dc.date.issued2020
dc.description.abstract2-(4-tert-butylbenzyl)propionaldehyde (trade names, e.g. lysmeral or lilial) is a fragrance chemical frequently used in cosmetic products where it is labelled as Butylphenyl methylpropional. A recently developed LC-MS/MS method for the analysis of four lysmeral metabolites (tert-butylbenzoic acid (TBBA), lysmerol, lysmerylic acid, and hydroxy-lysmerylic acid) was applied to 329 urine samples from the Environmental Specimen Bank collected between 2000 and 2018. The two major metabolites TBBA and lysmerol were found in quantifiable concentrations in almost all samples in this study and correlated significantly. Hence, both analytes proved to be specific biomarkers indicating the broad exposure to lysmeral. A significant decline was found for TBBA and lysmerol for the monitored years with the most pronounced decrease from 2012 to 2015. The daily intake (DI) was used to evaluate potential health risks with respect to the derived no-effect level (DNEL) as a threshold for exposure of the general population. The median DI (1.63 (my)g/kg bw/d) and the 95th percentile (4.69 (my)g/kg bw/d) corresponded to 2.6% and 7.5% of the lowest DNEL (62.5 (my)g/kg bw/d for oral administration), respectively. Even though a decreasing trend in exposure was observed the data still calls for efforts to reduce the exposure towards lysmeral since metabolites of lysmeral were detected in nearly all samples and adverse effects cannot be excluded. Clearly, these results need to be substantiated by HBM campaigns in population representative samples like the German Environmental Survey in adults (GerES VI) to provide more robust data for the adult population. © 2020 The Author(s)en
dc.format.extent1 Onlineresource (7 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-695
dc.identifier.urihttps://openumwelt.de/handle/123456789/4006
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectUmweltprobenbank
dc.titleHuman Biomonitoring in urine samples from the Environmental Specimen Bank reveals a decreasing trend over time in the exposure to the fragrance chemical lysmeral from 2000 to 2018
dc.title.alternativeHuman Biomonitoring in urine samples from the Environmental Specimen Bank reveals a decreasing trend over time in the exposure to the fragrance chemical lysmeral from 2000 to 2018
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleChemosphere
local.bibliographicCitation.originalDOI10.1016/j.chemosphere.2020.128955
local.bibliographicCitation.volume(2020), Heft In Press
local.collectionAufsätze
local.contributor.authorId02179919
local.contributor.authorId02184266
local.identifier.catalogId02479204
local.ingest.leader05529naa a2200000uu 4500
local.jointTitleHUMAN BIOMONITORING IN URINE SAMPLES FROM THE ENVIRONMENTAL SPECIMEN BANK REVEALS A DECREASING TREND OVER TIME IN THE EXPOSURE TO THE FRAGRANCE CHEMICAL LYSMERAL FROM 2000 TO 2018
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relation.isAuthorOfPublication800537d2-ed95-4cc9-973c-d54784b3cb09
relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
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