Publikation:
N-methylmalonamic acid (NMMA) as metabolite of methylisothiazolinone and methylchloroisothiazolinone in 24-h urine samples of the German Environmental Specimen Bank from 2000 to 2017

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dc.contributor.authorSchettgen, Thomas
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorRüther, Maria
dc.contributor.authorWeber, Till
dc.date.accessioned2024-06-16T14:28:15Z
dc.date.available2024-06-16T14:28:15Z
dc.date.issued2020
dc.description.abstractMethylisothiazolinone (MI) and the mixture of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI, 3:1) are widespread biocides used in cosmetics, household products, paints or as disinfectant in air-conditioning systems. Exposure to these compounds has raised concerns due to their sensitizing potential, as rates of skin sensitization were reported to increase in the last decade. We have analyzed N-methylmalonamic acid (NMMA), a common metabolite of MI and MCI in 24-h urine samples of the German Environmental Specimen Bank collected from 480 participants (240 male/240 female) between the years 2000 and 2017. Using these data, we were able to calculate the overall daily intake of MI and/or MCI/MI (3:1) of the study participants and point out time trends. NMMA was determined in all urine samples investigated above the LOQ of 0.5 (my)g/L urine. Median and 95th percentile level of NMMA in all 24-h urine samples was 4.1 (my)g/g creatinine and 8.5 (my)g/g creatinine, respectively. This would correspond to a median and 95th percentile daily intake of 0.35 (my)g/kg bw and 0.71 (my)g/kg bw for exclusive uptake of MI and 0.64 (my)g/kg bw and 1.28 (my)g/kg bw for exclusive uptake of MCI/MI (3:1). We noted only slight variations over time for median exposures, but an increasing time trend in the 95th percentile exposure between 2006 and 2011 with a decrease in recent years, probably reflecting regulatory measures on MI and MCI/MI (3:1) in cosmetic products. Increasing knowledge on determinants of exposure to MI and/or MCI/MI (3:1) would be necessary to further lower exposure to these sensitizing compounds. © 2019 Elsevier Ltd. All rights reserved.en
dc.format.extent1 Onlineressource (7 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-675
dc.identifier.urihttps://openumwelt.de/handle/123456789/4700
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectExpositionsabschätzung
dc.titleN-methylmalonamic acid (NMMA) as metabolite of methylisothiazolinone and methylchloroisothiazolinone in 24-h urine samples of the German Environmental Specimen Bank from 2000 to 2017
dc.title.alternativeN-methylmalonamic acid (NMMA) as metabolite of methylisothiazolinone and methylchloroisothiazolinone in 24-h urine samples of the German Environmental Specimen Bank from 2000 to 2017
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleChemosphere
local.bibliographicCitation.originalDOI10.1016/j.chemosphere.2019.125743
local.bibliographicCitation.volume246 (2020)
local.collectionAufsätze
local.contributor.authorId(DE-588)131477935
local.contributor.authorId02082994
local.identifier.catalogId02472310
local.ingest.leader05828naa a2200000uu 4500
local.jointTitleNMETHYLMALONAMIC ACID NMMA AS METABOLITE OF METHYLISOTHIAZOLINONE AND METHYLCHLOROISOTHIAZOLINONE IN 24H URINE SAMPLES OF THE GERMAN ENVIRONMENTAL SPECIMEN BANK FROM 2000 TO 2017 EXPOSURE AND TIME TRENDS
local.reviewtrue
local.sourcecatalog
local.staffPublicationtrue
local.subtitleexposure and time trends
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relation.isAuthorOfPublicationc35f06f5-f304-499f-b7b3-442daea221d8
relation.isAuthorOfPublication800537d2-ed95-4cc9-973c-d54784b3cb09
relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
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