Publikation:
A human biomonitoring study assessing glyphosate and Aminomethylphosphonic Acid (AMPA) exposures among farm and non-farm families

Kurzanzeige
dc.contributor.authorConnolly, Alison
dc.contributor.authorKoch, Holger Martin
dc.contributor.authorBury, Daniel
dc.contributor.authorConrad, André
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorMurawski, Aline
dc.date.accessioned2024-06-16T13:10:05Z
dc.date.available2024-06-16T13:10:05Z
dc.date.issued2022
dc.description.abstractGlyphosate-based pesticides are the highest-volume used herbicides worldwide. International concerns regarding the potential human adverse effects of glyphosate exposures have heightened since IARC classified glyphosate as probably carcinogenic to humans. Human biomonitoring (HBM) studies have identified ubiquitous exposure to glyphosate and its main breakdown product, aminomethylphosphonic acid (AMPA), from environmental exposures. The IMAGE research project aimed to investigate farm and non-farm families' exposure to glyphosate while aligning with the Human Biomonitoring for Europe (HBM4EU) initiative. The study recruited non-farm and farm families (who use glyphosate on their farms). Each family member provided a urine sample that was analysed using gas chromatography coupled with tandem mass spectrometry, with a limit of quantification of 0.05 (micro)g/L for glyphosate and AMPA. In addition to general information on background exposures in farm and non-farm families, we investigated relationships in exposure between families and family members. We recruited 68 families, including 54 non-farm and 14 farm families (180 vs. 45 individuals). Some pesticide users (n = 14, all male farmers) had slightly elevated AMPA levels compared to other adult participants but, overall, we observed no significant differences between farm and non-farm families. The main metabolite, AMPA, was quantifiable in twice as many samples as glyphosate (61% vs. 32%), with a maximum concentration of 7.24 (micro)g/L vs. 3.21 (micro)g/L. Compared to previous studies, exposure levels were relatively low and far below current health-based guidance values (3% or less for glyphosate and AMPA). Study results suggest potential exposures from residential co-exposures or living with a pesticide user. This is the first study internationally to investigate glyphosate and AMPA across family members (farm and non-farm). We found comparably low glyphosate and AMPA exposures among these families. These results enhance our understanding of glyphosate exposures for different demographic groups and contribute to the scientific knowledge on exposures required for regulatory risk assessments and the re-evaluation of glyphosate in 2022 by the European Commission. © 2022 by the authorsen
dc.format.extent1 Onlineresource (15 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-584
dc.identifier.urihttps://openumwelt.de/handle/123456789/2571
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBiomonitoring
dc.subjectUmweltbelastung
dc.subjectExpositionsabschätzung
dc.titleA human biomonitoring study assessing glyphosate and Aminomethylphosphonic Acid (AMPA) exposures among farm and non-farm families
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxics
local.bibliographicCitation.originalDOI10.3390/toxics10110690
local.bibliographicCitation.volume10 (2022), Heft 11
local.collectionAufsätze
local.contributor.authorId02182918
local.contributor.authorId02110258
local.contributor.authorId02172065
local.identifier.catalogId02494088
local.ingest.leader07019naa a2200000uu 4500
local.jointTitleA HUMAN BIOMONITORING STUDY ASSESSING GLYPHOSATE AND AMINOMETHYLPHOSPHONIC ACID AMPA EXPOSURES AMONG FARM AND NONFARM FAMILIES
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
relation.isAuthorOfPublicationbb0eb320-1a69-4eb7-8a9a-2be778f049d7
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublication1cf84dc6-c2cf-42ad-a5a7-f540c343a6e7
relation.isAuthorOfPublication.latestForDiscoverybb0eb320-1a69-4eb7-8a9a-2be778f049d7
Dateien
Sammlungen
Aufsätze