Publikation:
Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

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dc.contributor.authorDrakvik, Elina
dc.contributor.authorAltenburger, Rolf
dc.contributor.authorAoki, Yasunobu
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorReiber, Lena
dc.date.accessioned2024-06-16T14:32:55Z
dc.date.available2024-06-16T14:32:55Z
dc.date.issued2020
dc.description.abstractThe number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, "Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment" was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages: - We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures.<BR> - Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors.<BR> - Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps. <BR> - A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient. © 2019 The Authors. Published by Elsevier Ltd.en
dc.format.extent1 Onlineressource (7 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-495
dc.identifier.urihttps://openumwelt.de/handle/123456789/4943
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectUmweltchemikalien
dc.subjectRisikomanagement
dc.titleStatement on advancing the assessment of chemical mixtures and their risks for human health and the environment
dc.title.alternativeStatement on advancing the assessment of chemical mixtures and their risks for human health and the environment
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironment International
local.bibliographicCitation.originalDOI10.1016/j.envint.2019.105267
local.bibliographicCitation.volume134 (2020)
local.collectionAufsätze
local.contributor.authorId02183201
local.contributor.authorId02002954
local.contributor.authorId02077655
local.contributor.authorId(DE-588)108244233X
local.identifier.catalogId02470306
local.ingest.leader06404naa a2200000uu 4500
local.jointTitleSTATEMENT ON ADVANCING THE ASSESSMENT OF CHEMICAL MIXTURES AND THEIR RISKS FOR HUMAN HEALTH AND THE ENVIRONMENT
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