Publikation:
Metabolites of the fragrance 2-(4-tert-butylbenzyl)propionaldehyde (lysmeral) in urine of children and adolescents in Germany - Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)

Kurzanzeige
dc.contributor.authorFiedler, Nina
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorMurawski, Aline
dc.contributor.authorRucic, Enrico
dc.contributor.authorSchmied-Tobies, Maria Irene Hilde
dc.contributor.authorSchwedler, Gerda
dc.date.accessioned2024-06-16T14:06:34Z
dc.date.available2024-06-16T14:06:34Z
dc.date.issued2020
dc.description.abstractThe synthetic fragrance 2-(4-tert-butylbenzyl)propionaldehyde, also known as lysmeral, butylphenyl methylpropional, lilial, or lily aldehyde, is widely used in cosmetics, personal care products, laundry detergents, and air fresheners. It is classified as suspected to be harmful to fertility and possibly endocrine disrupting. Its maximum concentration in cosmetics is limited. First-morning void urine samples (N = 2133) were analysed for several metabolites of lysmeral (Chemical Abstract Service (CAS) No.: 80-54-6). Samples were collected in the population-representative German Environmental Survey for Children and Adolescents 2014-2017 (GerES V) from German residents aged 3-17 years. Four main metabolites tert-butylbenzoic acid, lysmerol, lysmerylic acid, and hydroxy-lysmerylic acid were found in quantifiable amounts in 100%, 99%, 40%, and 23% of the samples, respectively, with geometric mean concentrations of 10.21 my g/L (8.658 my g/gcrea) for tert-butylbenzoic acid, 1.528 my g/L (1.296 my g/gcrea) for lysmerol, and below the limit of quantification of 0.2 my g/L and 0.4 my g/L for lysmerylic acid and hydroxy-lysmerylic acid, respectively. Girls had higher urinary concentrations of lysmeral metabolites than boys. Usage of fragrances, fabric softener, and personal care products, especially perfume, was positively associated with urinary concentrations of lysmeral metabolites. Source identification builds a basis to derive proposals for reduction of exposure. These results can also provide the foundation for developing reference values for urinary metabolite concentrations of lysmeral in children and adolescents in Germany that will facilitate recognising future exposure trends. © 2020 The Author(s).en
dc.format.extent1 Onlineresource (6 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-480
dc.identifier.urihttps://openumwelt.de/handle/123456789/4238
dc.language.isoger
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectEndokriner Disruptor
dc.subjectExposition
dc.titleMetabolites of the fragrance 2-(4-tert-butylbenzyl)propionaldehyde (lysmeral) in urine of children and adolescents in Germany - Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)
dc.title.alternativeMetabolites of the fragrance 2-(4-tert-butylbenzyl)propionaldehyde (lysmeral) in urine of children and adolescents in Germany - Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2020.113594
local.bibliographicCitation.volume229 (2020)
local.collectionAufsätze
local.contributor.authorId(DE-588)1164813641
local.contributor.authorId(DE-588)1125139706
local.identifier.catalogId02476547
local.ingest.leader06251naa a2200000uu 4500
local.jointTitleMETABOLITES OF THE FRAGRANCE 24TERTBUTYLBENZYLPROPIONALDEHYDE LYSMERAL IN URINE OF CHILDREN AND ADOLESCENTS IN GERMANY HUMAN BIOMONITORING RESULTS OF THE GERMAN ENVIRONMENTAL SURVEY 20142017 GERES V
local.reviewtrue
local.sourcecatalog
local.staffPublicationtrue
relation.isAuthorOfPublicationb3fdf6e4-ff6e-41f5-bae3-a1c05ed47fad
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublication1cf84dc6-c2cf-42ad-a5a7-f540c343a6e7
relation.isAuthorOfPublication45fcaec1-fa8f-497c-baed-4384fd6c9e91
relation.isAuthorOfPublication145c9bab-4564-4392-99a4-8d8ec7b49a2e
relation.isAuthorOfPublicationee4958c4-4fef-4a6e-b037-66c5ae3c6e21
relation.isAuthorOfPublication.latestForDiscoveryb3fdf6e4-ff6e-41f5-bae3-a1c05ed47fad
Dateien
Sammlungen
Aufsätze