Publikation:
Human urinary arsenic species, associated exposure determinants and potential health risks assessed in the HBM4EU Aligned Studies

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dc.contributor.authorBuekers, Jurgen
dc.contributor.authorBaken, Kirsten
dc.contributor.authorGovarts, Eva
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorVogel, Nina
dc.date.accessioned2024-06-16T12:59:50Z
dc.date.available2024-06-16T12:59:50Z
dc.date.issued2023
dc.description.abstractThe European Joint Programme HBM4EU coordinated and advanced human biomonitoring (HBM) in Europe in order to provide science-based evidence for chemical policy development and improve chemical management. Arsenic (As) was selected as a priority substance under the HBM4EU initiative for which open, policy relevant questions like the status of exposure had to be answered. Internal exposure to inorganic arsenic (iAs), measured as Toxic Relevant Arsenic (TRA) (the sum of As(III), As(V), MMA, DMA) in urine samples of teenagers differed among the sampling sites (BEA (Spain) > Riksmaten adolescents (Sweden), ESTEBAN (France) > FLEHS IV (Belgium), SLO CRP (Slovenia)) with geometric means between 3.84 and 8.47 mikrog/L. The ratio TRA to TRA + arsenobetaine or the ratio TRA to total arsenic varied between 0.22 and 0.49. Main exposure determinants for TRA were the consumption of rice and seafood. When all studies were combined, Pearson correlation analysis showed significant associations between all considered As species. Higher concentrations of DMA, quantitatively a major constituent of TRA, were found with increasing arsenobetaine concentrations, a marker for organic As intake, e.g. through seafood, indicating that other sources of DMA than metabolism of inorganic As exist, e.g. direct intake of DMA or via the intake of arsenosugars or -lipids. Given the lower toxicity of DMA(V) versus iAs, estimating the amount of DMA not originating from iAs, or normalizing TRA for arsenobetaine intake could be useful for estimating iAs exposure and risk. Comparing urinary TRA concentrations with formerly derived biomonitoring equivalent (BE) for non-carcinogenic effects (6.4 mikrog/L) clearly shows that all 95th percentile exposure values in the different studies exceeded this BE. This together with the fact that cancer risk may not be excluded even at lower iAs levels, suggests a possible health concern for the general population of Europe. © 2023 The Authorsen
dc.format.extent1 Online-Ressource (12 Seiten)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-466
dc.identifier.urihttps://openumwelt.de/handle/123456789/2182
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectArsen
dc.subjectExposition
dc.titleHuman urinary arsenic species, associated exposure determinants and potential health risks assessed in the HBM4EU Aligned Studies
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2023.114115
local.bibliographicCitation.volume248 (2023)
local.collectionAufsätze
local.contributor.authorId02157105
local.contributor.authorId02191685
local.contributor.authorId02160044
local.identifier.catalogId02496650
local.ingest.leader06132naa a2200000uu 4500
local.jointTitleHUMAN URINARY ARSENIC SPECIES ASSOCIATED EXPOSURE DETERMINANTS AND POTENTIAL HEALTH RISKS ASSESSED IN THE HBM4EU ALIGNED STUDIES
local.reviewtrue
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local.source.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
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