Publikation:
Risk assessment of dietary exposure to organophosphorus flame retardants in children by using HBM-Data

Kurzanzeige
dc.contributor.authorPlichta, Veronika
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorSteinwider, Johann
dc.contributor.authorVogel, Nina
dc.contributor.authorWeber, Till
dc.date.accessioned2024-06-16T13:16:50Z
dc.date.available2024-06-16T13:16:50Z
dc.date.issued2022
dc.description.abstractDue to their extensive usage, organophosphorus flame retardants (OPFRs) have been detected in humans and in the environment. Human are exposed to OPFRs via inhalation of indoor air, dust uptake or dietary uptake through contaminated food and drinking water. Only recently, few studies addressing dietary exposure to OPFRs were published. In this study, we used human biomonitoring (HBM) data of OPFRs to estimate how much the dietary intake may contribute to the total exposure. We estimated by reverse dosimetry, the daily intake of tris (2-chloroethyl) phosphate (TCEP), tris (1-chloro-2-propyl) phosphate (TCIPP), tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) for children using HBM data from studies with sampling sites in Belgium, Denmark, France, Germany, Slovenia and Slovakia. For estimating the dietary exposure, a deterministic approach was chosen. The occurrence data of selected food categories were used from a published Belgium food basket study. Since the occurrence data were left-censored, the Lower bound (LB)-Upper bound (UB) approach was used. The estimated daily intake (EDI) calculated on the basis of urine metabolite concentrations ranged from 0.03 to 0.18 (micro)g/kg bw/d for TDCIPP, from 0.05 to 0.17 (micro)g/kg bw/d for TCIPP and from 0.02 to 0.2 (micro)g/kg bw/d for TCEP. Based on national food consumption data and occurrence data, the estimated dietary intake for TDCIPP ranged from 0.005 to 0.09 (mircro)g/kg bw/d, for TCIPP ranged from 0.037 to 0.2 (mirco)g/kg bw/d and for TCEP ranged from 0.007 to 0.018 (mirco)g/kg bw/d (summarized for all countries). The estimated dietary intake of TDCIPP contributes 11-173% to the EDI, depending on country and LB-UB scenario. The estimated dietary uptake of TCIPP was in all calculations, except in Belgium and France, above 100%. In the case of TCEP, it is assumed that the dietary intake ranges from 6 to 57%. The EDI and the estimated dietary intake contribute less than 3% to the reference dose (RfD). Therefore, the estimated exposure to OPFRs indicates a minimal health risk based on the current knowledge of available exposure, kinetic and toxicity data. We were able to show that the dietary exposure can have an impact on the general exposure based on our underlying exposure scenarios. © 2022 by the authorsen
dc.format.extent1 Onlineresource (12 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-449
dc.identifier.urihttps://openumwelt.de/handle/123456789/2766
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleRisk assessment of dietary exposure to organophosphorus flame retardants in children by using HBM-Data
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxics
local.bibliographicCitation.originalDOI10.3390/toxics10050234
local.bibliographicCitation.volume10 (2022), Heft 5
local.collectionAufsätze
local.contributor.authorId02189826
local.contributor.authorId(DE-588)1154605515
local.contributor.authorId02189827
local.identifier.catalogId02490653
local.ingest.leader06104naa a2200000uu 4500
local.jointTitleRISK ASSESSMENT OF DIETARY EXPOSURE TO ORGANOPHOSPHORUS FLAME RETARDANTS IN CHILDREN BY USING HBMDATA
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublicationb5969380-709f-49f3-9d11-d6293091c343
relation.isAuthorOfPublication800537d2-ed95-4cc9-973c-d54784b3cb09
relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
Dateien
Sammlungen
Aufsätze