Publikation:
Biomonitoring of occupational exposure to phthalates: a systematic review

Kurzanzeige
dc.contributor.authorFréry, Nadine
dc.contributor.authorSantonen, Tiina
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorPorras, Simo P.
dc.date.accessioned2024-06-16T14:04:51Z
dc.date.available2024-06-16T14:04:51Z
dc.date.issued2020
dc.description.abstractIntroduction Phthalates, a group of ubiquitous industrial chemicals, have been widely used in occupational settings, mainly as plasticizers in a variety of applications. Occupational exposure to different phthalates has been studied in several occupational settings using human biomonitoring (HBM). Aim To provide a comprehensive review of the available literature on occupational exposure to phthalates assessed using HBM and to determine future data needs on the topic as part of the HBM4EU project. Methods A systematic search was carried out in the databases of Pubmed, Scopus, and Web of Science for articles published between 2000 and September 4, 2019 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 22 studies on the occupational HBM of phthalates was considered suitable for review. Results and discussion Among the reviewed studies, 19 (86%) focused on DEHP, an old phthalate that is now subject to authorization and planned to be restricted in the EU. Concentrations of MEHHP, one of its metabolites, varied up to 13-fold between studies and across sectors when comparing extreme geometric means, ranging from 11.6 (similar to the general populations) to 151 ÎÌg/g creatinine. Only 2 studies focused on newer phthalates such as DiNP and DPHP. Concerning the geographical distribution, 10 studies were performed in Europe (including 6 in Slovakia), 8 in Asia, and 4 in North America, but this distribution is not a good reflection of phthalate production and usage levels worldwide. Most HBM studies were performed in the context of PVC product manufacturing. Future studies should focus on: i) a more uniform approach to sampling timing to facilitate comparisons between studies; ii) newer phthalates; and iii) old phthalates in waste management or recycling. Conclusion Our findings highlight the lack of recent occupational HBM studies on both old and new phthalate exposure in European countries and the need for a harmonized approach. Considering the important policy actions taken in Europe regarding phthalates, it seems relevant to evaluate the impact of these actions on exposure levels and health risks for workers. © 2020 The Authorsen
dc.format.extent1 Onlineresource (22 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-381
dc.identifier.urihttps://openumwelt.de/handle/123456789/4170
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.titleBiomonitoring of occupational exposure to phthalates: a systematic review
dc.title.alternativeBiomonitoring of occupational exposure to phthalates: a systematic review
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2020.113548
local.bibliographicCitation.volume229 (2020)
local.collectionAufsätze
local.contributor.authorId02167251
local.contributor.authorId02134975
local.contributor.authorId02185008
local.identifier.catalogId02477069
local.ingest.leader05825naa a2200000uu 4500
local.jointTitleBIOMONITORING OF OCCUPATIONAL EXPOSURE TO PHTHALATES A SYSTEMATIC REVIEW
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