Publikation:
Chemicals and cell-based assays in drinking water sources in Manhiça, Mozambique

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dc.contributor.authorVillanueva, Cristina M.
dc.contributor.authorGrau-Pujol, Berta
dc.contributor.authorEvlampidou, Iro
dc.contributor.authorGrummt, Tamara
dc.contributor.authorKuckelkorn, Jochen
dc.date.accessioned2024-06-16T13:29:52Z
dc.date.available2024-06-16T13:29:52Z
dc.date.issued2021
dc.description.abstractBackground The chemical quality of drinking water is widely unknown in low-income countries. Objective We conducted an exploratory study in Manhiça district (Mozambique) to evaluate drinking water quality using chemical analyses and cell-based assays. Methods We measured nitrate, fluoride, metals, pesticides, disinfection by-products, and industrial organochlorinated chemicals, and conducted the bioassays Ames test for mutagenicity, micronuclei assay (MN-FACS), ER-CALUX, and antiAR-CALUX in 20 water samples from protected and unprotected sources. Results Nitrate was present in all samples (median 7.5†mg/L). Manganese, cobalt, chromium, aluminium, and barium were present in 90-100% of the samples, with median values of 32, 0.6, 2.0, 61, 250†(mirco)g/l, respectively. Manganese was above 50†ÎÌg/l (EU guideline) in eight samples. Arsenic, lead, nickel, iron, and selenium median values were below the quantification limit. Antimony, cadmium, copper, mercury, zinc and silver were not present. Trihalomethanes, haloacetic acids, haloacetonitriles and haloketones were present in 5-28% samples at levels </=4.6†(micro)g/l. DDT, dieldrin, diuron, and pirimiphos-methyl were quantified in 2, 3, 3, and 1 sample, respectively (range 12-60†ng/L). Fluoride was present in one sample (0.11†mg/l). Trichloroethene and tetrachloroethene were not present. Samples were negative in the in vitro assays. Significance Results suggest low exposure to chemicals, mutagenicity, genotoxicity and endocrine disruption through drinking water in Manhiça population. High concentration of manganese in some samples warrants confirmatory studies, given the potential link to impaired neurodevelopment. © 2021, The Author(s), under exclusive licence to Springer Nature Americaen
dc.format.extent1 Onlineresource (pages 276-288)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-378
dc.identifier.urihttps://openumwelt.de/handle/123456789/3083
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectTrinkwasser
dc.subjectChemikalien
dc.subjectMocambique
dc.titleChemicals and cell-based assays in drinking water sources in Manhiça, Mozambique
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleJournal of exposure science and environmental epidemiology
local.bibliographicCitation.originalDOI10.1038/s41370-020-00282-5
local.bibliographicCitation.volume31 (2021)
local.collectionAufsätze
local.contributor.authorId02141238
local.contributor.authorId02188921
local.contributor.authorId02188922
local.identifier.catalogId02487677
local.ingest.leader06087naa a2200000uu 4500
local.jointTitleCHEMICALS AND CELLBASED ASSAYS IN DRINKING WATER SOURCES IN MANHIA MOZAMBIQUE
local.reviewtrue
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relation.isAuthorOfPublication.latestForDiscovery19f128e0-8121-4b29-a9db-b75a1a2b1c4b
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