Publikation:
Concept for the evaluation of carcinogenic substances in population-based human biomonitoring

Kurzanzeige
dc.contributor.authorWollin, Klaus-Michael
dc.contributor.authorApel, Petra
dc.contributor.authorChovolou, Yvonni
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.organisationOtherDeutschland. Umweltbundesamt. Kommission Human-Biomonitoring
dc.date.accessioned2024-06-16T13:16:15Z
dc.date.available2024-06-16T13:16:15Z
dc.date.issued2022
dc.description.abstractThe Human Biomonitoring (HBM) Commission at the German Environment Agency holds the opinion that for environmental carcinogens for which no exposure levels can be assumed and are harmless to health, health-based guidance values corresponding to the classical definition of the HBM-I or HBM-II value cannot be established. Therefore, only reference values have been derived so far for genotoxic carcinogens from exposure data of the general population or subpopulations. The concept presented here opens up the possibility of performing health risk assessments of carcinogenic substances in human biomonitoring, and thus goes decisively beyond the purely descriptive statistical reference value concept. Using the presented method, quantitative dose descriptors of internal exposure can be derived from those of external exposure, provided that sufficient toxicokinetic information is available. Dose descriptors of internal exposure then allow the simple estimate of additional lifetime cancer risks for measured biomarker concentrations or, conversely, of equivalent concentrations for selected risks, such as those considered as tolerable for the general population. HBM data of chronic exposures to genotoxic carcinogens can thus be used to assess the additional lifetime cancer risk referring to the general population and to justify and prioritize risk management measures. © 2022 by the authorsen
dc.format.extent1 Onlineresource (13 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-356
dc.identifier.urihttps://openumwelt.de/handle/123456789/2751
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectRisikoanalyse
dc.titleConcept for the evaluation of carcinogenic substances in population-based human biomonitoring
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Environmental Research and Public Health
local.bibliographicCitation.originalDOI10.3390/ijerph19127235
local.bibliographicCitation.volume19 (2022), Heft 12
local.collectionAufsätze
local.contributor.authorId00309918
local.contributor.authorId02189853
local.identifier.catalogId02490879
local.ingest.leader05731naa a2200000uu 4500
local.jointTitleCONCEPT FOR THE EVALUATION OF CARCINOGENIC SUBSTANCES IN POPULATIONBASED HUMAN BIOMONITORING CONCEPT PAPER
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
local.subtitleConcept Paper
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relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublication.latestForDiscovery28f9b1e3-5211-44ba-8d52-c462cd5fe32d
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