Publikation:
PFASs: What can we learn from the European Human Biomonitoring Initiative HBM4EU

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dc.contributor.authorUhl, Maria
dc.contributor.authorSchoeters, Greet
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorGovarts, Eva
dc.date.accessioned2024-06-16T12:53:34Z
dc.date.available2024-06-16T12:53:34Z
dc.date.issued2023
dc.description.abstractPer- and polyfluoroalkyl substances (PFASs) were one of the priority substance groups selected which have been investigated under the ambitious European Joint programme HBM4EU (2017-2022). In order to answer policy relevant questions concerning exposure and health effects of PFASs in Europe several activities were developed under HBM4EU namely i) synthesis of HBM data generated in Europe prior to HBM4EU by developing new platforms, ii) development of a Quality Assurance/Quality Control Program covering 12 biomarkers of PFASs, iii) aligned and harmonized human biomonitoring studies of PFASs. In addition, some cohort studies (on mother-child exposure, occupational exposure to hexavalent chromium) were initiated, and literature researches on risk assessment of mixtures of PFAS, health effects and effect biomarkers were performed. The HBM4EU Aligned Studies have generated internal exposure reference levels for 12 PFASs in 1957 European teenagers aged 12-18 years. The results showed that serum levels of 14.3% of the teenagers exceeded 6.9 (micro)g/L PFASs, which corresponds to the EFSA guideline value for a tolerable weekly intake (TWI) of 4.4 ng/kg for some of the investigated PFASs (PFOA, PFOS, PFNA and PFHxS). In Northern and Western Europe, 24% of teenagers exceeded this level. The most relevant sources of exposure identified were drinking water and some foods (fish, eggs, offal and locally produced foods). HBM4EU occupational studies also revealed very high levels of PFASs exposure in workers (P95: 192 (micro)g/L in chrome plating facilities), highlighting the importance of monitoring PFASs exposure in specific workplaces. In addition, environmental contaminated hotspots causing high exposure to the population were identified. In conclusion, the frequent and high PFASs exposure evidenced by HBM4EU strongly suggests the need to take all possible measures to prevent further contamination of the European population, in addition to adopting remediation measures in hotspot areas, to protect human health and the environment. HBM4EU findings also support the restriction of the whole group of PFASs. Further, research and definition for additional toxicological dose-effect relationship values for more PFASs compounds is needed.en
dc.format.extent9 pages
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-257
dc.identifier.urihttps://openumwelt.de/handle/123456789/2058
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectExposition
dc.titlePFASs: What can we learn from the European Human Biomonitoring Initiative HBM4EU
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Hygiene and Environmental Health
local.bibliographicCitation.originalDOI10.1016/j.ijheh.2023.114168
local.bibliographicCitation.volume250 (2023)
local.collectionAufsätze
local.contributor.authorId02068904
local.contributor.authorId02146007
local.contributor.authorId02160044
local.identifier.catalogId02497552
local.ingest.leader06135naa a2200000uu 4500
local.jointTitlePFASS WHAT CAN WE LEARN FROM THE EUROPEAN HUMAN BIOMONITORING INITIATIVE HBM4EU
local.reviewtrue
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local.source.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.de
local.staffPublicationtrue
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