Publikation:
Chemical mixtures in the EU population: composition and potential risks

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dc.contributor.authorSocianu, Sebastian
dc.contributor.authorBopp, Stephanie
dc.contributor.authorGovarts, Eva
dc.contributor.authorKolossa-Gehring, Marike
dc.date.accessioned2024-06-16T13:10:41Z
dc.date.available2024-06-16T13:10:41Z
dc.date.issued2022
dc.description.abstractRegulating chemical mixtures is a complex scientific and policy task. The aim of this study was to investigate typical mixtures and their potential risks based on internal exposure levels in the European population. Based on human biomonitoring (HBM) data made available via the HBM4EU project, we derived generic mixtures representative of a median (P50) and a worst-case scenario (P95) for adults and children. We performed a mixture risk assessment based on HBM concentrations, health-based guidance values (HBGVs) as internal thresholds of concern, and the conservative assumption of concentration addition applied across different toxicological endpoints. Maximum cumulative ratios (MCRs) were calculated to characterize the mixture risk. The mixtures comprise 136 biomarkers for adults and 84 for children, although concentration levels could be quantified only for a fraction of these. Due to limited availability of HBGVs, the mixture risk was assessed for a subset of 20 substance-biomarker pairs for adults and 17 for children. The mixture hazard index ranged from 2.8 (P50, children) to 9.2 (P95, adults). Six to seven substances contributed to over 95% of the total risk. MCR values ranged between 2.6 and 5.5, which is in a similar range as in previous studies based on human external exposures assessments. The limited coverage of substances included in the calculations and the application of a hazard index across toxicological endpoints argue for caution in the interpretation of the results. Nonetheless the analyses of MCR and MAFceiling can help inform a possible mixture assessment factor (MAF) applicable to single substance risk assessment to account for exposure to unintentional mixtures. © 2022 by the authorsen
dc.format.extent1 Onlineresource (18 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-248
dc.identifier.urihttps://openumwelt.de/handle/123456789/2614
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.titleChemical mixtures in the EU population: composition and potential risks
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleInternational Journal of Environmental Research and Public Health
local.bibliographicCitation.originalDOI10.3390/ijerph19106121
local.bibliographicCitation.volume16 (2022)
local.collectionAufsätze
local.contributor.authorId02190369
local.contributor.authorId02181275
local.contributor.authorId02160044
local.identifier.catalogId02492887
local.ingest.leader05528naa a2200000uu 4500
local.jointTitleCHEMICAL MIXTURES IN THE EU POPULATION COMPOSITION AND POTENTIAL RISKS
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
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relation.isAuthorOfPublication.latestForDiscovery0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
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