Publikation:
Benzene metabolite SPMA and acrylamide metabolites AAMA and GAMA in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)

Kurzanzeige
dc.contributor.authorBethke, Robert
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorMurawski, Aline
dc.contributor.authorRucic, Enrico
dc.contributor.authorSchmied-Tobies, Maria Irene Hilde
dc.contributor.authorSchwedler, Gerda
dc.date.accessioned2024-06-16T14:01:04Z
dc.date.available2024-06-16T14:01:04Z
dc.date.issued2020
dc.description.abstractBenzene and acrylamide are carcinogenic substances contained inter alia in tobacco smoke. The mercapturic acid metabolites of benzene, N-acetyl-S-phenyl-L-cysteine (SPMA), and of acrylamide, N-acetyl-S-(3-amino-3-oxopropyl)-cysteine (AAMA) and N-acetyl-S-(3-amino-2-hydroxy-3-oxopropyl)-cysteine (GAMA), were analysed in 2260 first-morning void urine samples from children and adolescents aged 3-17 years, participating in the population-representative German Environmental Survey on Children and Adolescents, GerES V 2014-2017. SPMA was detected in 98% of the participants with a geometric mean (GM) of 0.097 (my)g/L urine. Smokers had about 10-fold higher levels of the benzene metabolite SPMA than non-smokers. The sample comprises of 48 self-reported smokers, mainly in the oldest age group (14-17-year-olds). Second-hand smoke exposure, living near busy or very busy roads, and using domestic fuels for heating were additionally associated with higher benzene metabolite levels. SPMA levels in GerES V were lower compared to levels found in other countries, which in part however may reflect different proportions of smokers. The acrylamide metabolites AAMA and GAMA were detected in 100% of the participants with a GM of 72.6 (my)g/L urine for AAMA and 15.0 (my)g/L urine for GAMA. Smoking children and adolescents had about 2.5-fold higher AAMA levels than non-smoking ones. The frequency of consumption of french-fried potatoes and potato crisps consumption was also positively associated with urinary AAMA and GAMA levels. Compared to the urinary AAMA and GAMA levels in Germany and other countries, levels in GerES V tended to be higher than in the few studies reported. The urinary levels of the benzene biomarker SPMA, and the acrylamide biomarkers AAMA and GAMA build the basis to derive reference values for the exposure of children and adolescents in Germany. The results reveal options for exposure reduction mainly in personal choices regarding smoking and diet, but also requiring policy to maintain efforts in non-smoking regulations and improving ambient air quality. Providing these results also to the European HBM Initiative HBM4EU will contribute to gain knowledge on the exposure of the European population, the health impact of carcinogens and thus providing support for substantiated exposure assessment. © 2020 The Author(s)en
dc.format.extent1 Onlineresource (9 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-66
dc.identifier.urihttps://openumwelt.de/handle/123456789/4062
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectExposition
dc.subjectKanzerogener Stoff
dc.subjectRauchen
dc.titleBenzene metabolite SPMA and acrylamide metabolites AAMA and GAMA in urine of children and adolescents in Germany - human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V)
dc.title.alternativeBenzene metabolite SPMA and acrylamide metabolites AAMA and GAMA in urine of children and adolescents in Germany
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleEnvironmental Research
local.bibliographicCitation.originalDOI10.1016/j.envres.2020.110295
local.bibliographicCitation.volume192 (2020)
local.collectionAufsätze
local.contributor.authorId(DE-588)1158378610
local.contributor.authorId(DE-588)1164813641
local.contributor.authorId(DE-588)1125139706
local.identifier.catalogId02478889
local.ingest.leader07261naa a2200000uu 4500
local.jointTitleBENZENE METABOLITE SPMA AND ACRYLAMIDE METABOLITES AAMA AND GAMA IN URINE OF CHILDREN AND ADOLESCENTS IN GERMANY HUMAN BIOMONITORING RESULTS OF THE GERMAN ENVIRONMENTAL SURVEY 20142017 GERES V
local.reviewtrue
local.sourcecatalog
local.staffPublicationtrue
relation.isAuthorOfPublication20f37133-90bb-4cf9-b950-d4ccb24d1919
relation.isAuthorOfPublication0c3b6c3e-eff4-42d8-94e9-07a4fee4049c
relation.isAuthorOfPublication1cf84dc6-c2cf-42ad-a5a7-f540c343a6e7
relation.isAuthorOfPublication45fcaec1-fa8f-497c-baed-4384fd6c9e91
relation.isAuthorOfPublication145c9bab-4564-4392-99a4-8d8ec7b49a2e
relation.isAuthorOfPublicationee4958c4-4fef-4a6e-b037-66c5ae3c6e21
relation.isAuthorOfPublication.latestForDiscovery20f37133-90bb-4cf9-b950-d4ccb24d1919
Dateien
Sammlungen
Aufsätze