Publikation:
Concurrent assessment of Phthalates/HEXAMOLL ® DINCH Exposure and Wechsler intelligence scale for children performance in three European cohorts of the HBM4EU aligned studies

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dc.contributor.authorRosolen, Valentina
dc.contributor.authorApel, Petra
dc.contributor.authorGiordani, Elisa
dc.contributor.authorMariuz, Marika
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorLange, Rosa
dc.date.accessioned2024-06-16T13:10:09Z
dc.date.available2024-06-16T13:10:09Z
dc.date.issued2022
dc.description.abstractInformation about the effects of phthalates and non-phthalate substitute cyclohexane-1,2-dicarboxylic acid diisononyl ester (HEXAMOLL® DINCH) on children's neurodevelopment is limited. The aim of the present research is to evaluate the association between phthalate/HEXAMOLL® DINCH exposure and child neurodevelopment in three European cohorts involved in HBM4EU Aligned Studies. Participating subjects were school-aged children belonging to the Northern Adriatic cohort II (NAC-II), Italy, Odense Child Cohort (OCC), Denmark, and PCB cohort, Slovakia. In each cohort, children's neurodevelopment was assessed through the Full-Scale Intelligence Quotient score (FSIQ) of the Wechsler Intelligence Scale of Children test using three different editions. The children's urine samples, collected for one point in time concurrently with the neurodevelopmental evaluation, were analyzed for several phthalates/HEXAMOLL® DINCH biomarkers. The relation between phthalates/HEXAMOLL® DINCH and FSIQ was explored by applying separate multiple linear regressions in each cohort. The means and standard deviations of FSIQ were 109 +/- 11 (NAC-II), 98 +/- 12 (OCC), and 81 +/- 15 (PCB cohort). In NAC-II, direct associations between FSIQ and DEHP's biomarkers were found: 5OH-MEHP+5oxo-MEHP (beta=2.56; 95% CI 0.58-4.55; N=270), 5OH-MEHP+5cx-MEPP (beta=2.48; 95% CI 0.47-4.49; N=270) and 5OH-MEHP (beta=2.58; 95% CI 0.65-4.51; N=270). On the contrary, in the OCC the relation between DEHP's biomarkers and FSIQ tended to be inverse but imprecise (p-value >/= 0.10). No associations were found in the PCB cohort. FSIQ was not associated with HEXAMOLL® DINCH in any cohort. In conclusion, these results do not provide evidence of an association between concurrent phthalate/DINCHHEXAMOLLR DINCH exposure and IQ in children. © 2022 by the authorsen
dc.format.extent1 Onlineresource (20 pages)
dc.format.mediumonline resource
dc.identifier.doihttps://doi.org/10.60810/openumwelt-17
dc.identifier.urihttps://openumwelt.de/handle/123456789/2579
dc.language.isoeng
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectHuman-Biomonitoring
dc.subjectDINCH
dc.subjectUmweltchemikalien
dc.titleConcurrent assessment of Phthalates/HEXAMOLL ® DINCH Exposure and Wechsler intelligence scale for children performance in three European cohorts of the HBM4EU aligned studies
dc.typeWissenschaftlicher Artikel
dc.type.dcmitext
dc.type.mediumcomputer
dspace.entity.typePublication
local.bibliographicCitation.journalTitleToxics
local.bibliographicCitation.originalDOI10.3390/toxics10090538
local.bibliographicCitation.volume10 (2022), Heft 9
local.collectionAufsätze
local.contributor.authorId02190753
local.contributor.authorId02190754
local.contributor.authorId02190755
local.identifier.catalogId02494045
local.ingest.leader06407naa a2200000uu 4500
local.jointTitleCONCURRENT ASSESSMENT OF PHTHALATESHEXAMOLL DINCH EXPOSURE AND WECHSLER INTELLIGENCE SCALE FOR CHILDREN PERFORMANCE IN THREE EUROPEAN COHORTS OF THE HBM4EU ALIGNED STUDIES
local.reviewtrue
local.sourcecatalog
local.source.urihttp://creativecommons.org/licenses/by/4.0/deed.de
local.staffPublicationtrue
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relation.isAuthorOfPublication278393f9-ea5a-4405-87ce-b9bdb9bfb28c
relation.isAuthorOfPublication.latestForDiscovery28f9b1e3-5211-44ba-8d52-c462cd5fe32d
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