Person: Brandt, Marc
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Veröffentlichung Integrated in silico strategy for PBT assessment and prioritization under REACH(2016) Pizzo, Fabiola; Lombardo, Anna; Manganaro, Alberto; Brandt, Marc; Cappelli, Claudia I.; Petoumenou, Maria I.; Albanese, Federica; Roncaglioni, Alessandra; Benfenati, EmilioChemicals may persist in the environment, bioaccumulate and be toxic for humans and wildlife, posing great concern. These three properties, persistence (P), bioaccumulation (B), and toxicity (T) are the key targets of the PBT-hazard assessment. The European regulation for the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) requires assessment of PBT-properties for all chemicals that are produced or imported in Europe in amounts exceeding 10 tonnes per year, checking whether the criteria set out in REACH Annex XIII are met, so the substance should therefore be considered to have properties of very high concern. Considering how many substances can fall under the REACH regulation, there is a pressing need for new strategies to identify and screen large numbers fast and inexpensively. An efficient non-testing screening approach to identify PBT candidates is necessary, as a valuable alternative to money- and time-consuming laboratory tests and a good start for prioritization since few tools exist (e.g. the PBT profiler developed by USEPA).
The aim of this work was to offer a conceptual scheme for identifying and prioritizing chemicals for further assessment and if appropriate further testing, based on their PBT-potential, using a non-testing screening approach. We integrated in silico models (using existing and developing new ones) in a final algorithm for screening and ranking PBT-potential, which uses experimental and predicted values as well as associated uncertainties. The Multi-Criteria Decision-Making (MCDM) theory was used to integrate the different values. Then we compiled a new set of data containing known PBT and non-PBT substances, in order to check how well our approach clearly differentiated compounds labeled as PBT from those labeled as non-PBT. This indicated that the integrated model distinguished between PBT from non-PBT compounds.
Quelle: http://www.sciencedirect.comVeröffentlichung Neustart der EU-Nachhaltigkeitspolitik(2016) Abeling, Thomas; Blum, Christopher; Brandt, Marc; Bünger, Björn; Burger, Andreas; Daschkeit, Achim; Ehlers, Knut; Ginzky, Harald; Günther, Jens; Kabel, Claudia; Koch-Jugl, Juliane; Knoche, Guido; Kosmol, Jan; Lambrecht, Martin; Langner, Marcel; Löwe, Christian; Matezki, Steffen; Matthey, Astrid; Mohaupt, Volker; Mönch, Lars; Mutert, Tina; Nöh, Ingrid; Oehme, Ines; Penn-Bressel, Gertrude; Richter, Marianne; Richter, Nadja; Richter, Simone; Rose, Johanna; Stolzenberg, Hans-Christian; Thierbach, Claudia; Wolke, Frank; Wuttke, Joachim; Deutschland. UmweltbundesamtAus Sicht des Umweltbundesamts (UBA) muss die EU-Nachhaltigkeitsstrategie novelliert werden, um die globalen Nachhaltigkeitsziele (Sustainable Development Goals, SDGs) auf EU-Ebene umzusetzen. Das Positionspapier benennt Zielsetzungen und Maßnahmen für eine nachhaltige Entwicklung in der EU. Quelle: UmweltbundesamtVeröffentlichung Collaborative decision support and documentation in chemical safety with KnowSEC(2016) Baumeister, Joachim; Striffler, Albrecht; Brandt, Marc; Neumann, MichaelTo protect the health of human and environment, the European Union implemented the REACH regulation for chemical substances. REACH is an acronym for Registration, Evaluation, Authorization, and Restriction of Chemicals. Under REACH, the authorities have the task of assessing chemical substances, especially those that might pose a risk to human health or environment. The work under REACH is scientifically, technically and procedurally a complex and knowledge-intensive task that is jointly performed by the European Chemicals Agency and member state authorities in Europe. The assessment of substances under REACH conducted in the German Environment Agency is supported by the knowledge-based system KnowSEC, which is used for the screening, documentation, and decision support when working on chemical substances. The software KnowSEC integrates advanced semantic technologies and strong problem solving methods. It allows for the collaborative work on substances in the context of the European REACH regulation. We discuss the applied methods and process models and we report on experiences with the implementation and use of the system.Quelle: http://jcheminf.springeropen.comVeröffentlichung Restart of the EU sustainability policy(2016) Abeling, Thomas; Blum, Christopher; Brandt, Marc; Bünger, Björn; Burger, Andreas; Daschkeit, Achim; Ehlers, Knut; Ginzky, Harald; Günther, Jens; Kabel, Claudia; Koch-Jugl, Juliane; Knoche, Guido; Kosmol, Jan; Lambrecht, Martin; Langner, Marcel; Löwe, Christian; Matezki, Steffen; Matthey, Astrid; Mohaupt, Volker; Mönch, Lars; Mutert, Tina; Nöh, Ingrid; Oehme, Ines; Penn-Bressel, Gertrude; Richter, Marianne; Richter, Nadja; Richter, Simone; Rose, Johanna; Stolzenberg, Hans-Christian; Thierbach, Claudia; Wolke, Frank; Wuttke, Joachim; Deutschland. UmweltbundesamtThe German Environment Agency (UBA) is in favour of a revision of the EU Sustainable Development Strategy in order to implement the Sustainable Devel opment Goals at European Level. The position paper of the German Environment Agency identifies objectives and required actions for sustainable development in the EU. Quelle: UmweltbundesamtVeröffentlichung A weight-of-evidence approach to assess chemicals: case study on the assessment of persistence of 4,6-substituted phenolic benzotriazoles in the environment(2016) Becker, Eva; Brandt, Marc; Jöhncke, Ulrich; Sättler, Daniel; Schulte, ChristophBackground
One important purpose of the European REACH Regulation (EC No. 1907/2006) is to promote the use of alternative methods for assessment of hazards of substances in order to avoid animal testing. Experience with environmental hazard assessment under REACH shows that efficient alternative methods are needed in order to assess chemicals when standard test data are missing. One such assessment method is the weight-of-evidence (WoE) approach. In this study, the WoE approach was used to assess the persistence of certain phenolic benzotriazoles, a group of substances including also such of very high concern (SVHC).
Results
For phenolic benzotriazoles, assessment of the environmental persistence is challenging as standard information, i.e. simulation tests on biodegradation are not available. Thus, the WoE approach was used: overall information resulting from many sources was considered, and individual uncertainties of each source analysed separately. In a second step, all information was aggregated giving an overall picture of persistence to assess the degradability of the phenolic benzotriazoles under consideration although the reliability of individual sources was incomplete.
Conclusions
Overall, the evidence suggesting that phenolic benzotriazoles are very persistent in the environment is unambiguous. This was demonstrated by a WoE approach considering the prerequisites of REACH by combining several limited information sources. The combination enabled a clear overall assessment which can be reliably used for SVHC identification. Finally, it is recommended to include WoE approaches as an important tool in future environmental risk assessments.
Quelle: https://enveurope.springeropen.comVeröffentlichung A new integrated in silico strategy for the assessment and prioritization(2016) Pizzo, Fabiola; Lombardo, Anna; Brandt, Marc; Manganaro, Alberto; Benfenati, Emilio