Person: Rucic, Enrico
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Veröffentlichung Hexamoll® DINCH and DPHP metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014-2017(2019) Conrad, André; Kolossa-Gehring, Marike; Rucic, Enrico; Schmied-Tobies, Maria Irene Hilde; Schulz, Christine; Schwedler, GerdaThe production and use of the plasticisers Hexamoll® DINCH (di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate) and DPHP (di-(2-propylheptyl) phthalate) have increased after both chemicals were introduced into the market in the early 2000s as substitutes for restricted high molecular weight phthalates. During the population representative German Environmental Survey (GerES) of Children and Adolescents (GerES V, 2014-2017), we collected urine samples and measured the concentrations of DINCH and DPHP metabolites in 2228 and in a subsample of 516 participants, respectively. We detected DINCH and DPHP metabolites in 100% and 62% of the 3-17 years old children and adolescents, respectively. Geometric means of DINCH metabolites were 2.27 myg/L for OH-MINCH, 0.93 myg/L for oxo-MINCH, 1.14 myg/L for cx-MINCH and 3.47 myg/L for DINCH (Sigma of OH-MINCH + cx-MINCH). Geometric means of DPHP metabolites were 0.30 myg/L for OH-MPHP, 0.32 myg/L for oxo-MPHP and 0.64 myg/L for DPHP (Sigma of OH-MPHP + oxo-MPHP). The 3-5 years old children had almost 3-fold higher DINCH biomarkers levels than adolescents (14-17 years). Higher concentrations of DPHP biomarkers among young children only became apparent after creatinine adjustment. Urinary levels of DINCH but not of DPHP biomarkers were associated with the levels of the respective plasticisers in house dust. When compared to HBM health-based guidance values, we observed no exceedance of the HBM-I value of 1 mg/L for DPHP (Sigma of OH-MPHP + oxo-MPHP). However, 0.04% of the children exceeded the health based guidance value HBM-I of 3 mg/L for DINCH (Sigma of OH-MINCH + cx-MINCH). This finding shows that even a less toxic replacement of restricted chemicals can reach exposures in some individuals, at which, according to current knowledge, health impacts cannot be excluded with sufficient certainty. In conclusion, we provide representative data on DINCH and DPHP exposure of children and adolescents in Germany. Further surveillance is warranted to assess the substitution process of plasticisers, and to advise exposure reduction measures, especially for highly exposed children and adolescents. Providing the results to the European HBM Initiative HBM4EU will support risk assessment and risk management not only in Germany but also in Europe. © 2019 The Authors. Published by Elsevier GmbHVeröffentlichung Die Deutsche Umweltstudie zur Gesundheit von Kindern und Jugendlichen, GerES V 2014-2017(2019) Bandow, Nicole; Conrad, André; Kolossa-Gehring, Marike; Murawski, Aline; Rucic, Enrico; Sawal, George; Schmied-Tobies, Maria Irene Hilde; Schwedler, GerdaDie junge Bevölkerung stand im Mittelpunkt der Deutschen Umweltstudie zur Gesundheit von Kindern und Jugendlichen, GerES V, die vom Umweltbundesamt in den Jahren 2014 bis 2017 durchgeführt wurde. Dabei wurden mittels Human-Biomonitoring Schadstoffe im Urin und Blut von 3- bis 17-jährigen Kindern und Jugendlichen untersucht, um Aussagen über die aktuelle Belastungssituation in Deutschland treffen zu können. Beispiele weiterführender Auswertungen aus GerES V werden vorgestellt: die Analyse neuer Chemikalien, die Identifizierung besonders belasteter Gruppen, der Vergleich mit vorherigen Untersuchungen, die Ermittlung von Belastungsquellen und -pfaden sowie die gesundheitliche Bewertung der Belastung. Diese Ergebnisse eignen sich als Entscheidungsgrundlage für Maßnahmen und Regelungen zum Schutz von Umwelt und Gesundheit und dienen dem Ziel, eine gesunde Zukunft der Bevölkerung zu gestalten. In: UMID : Umwelt und Mensch - Informationsdienst ; Umwelt & Gesundheit, Umweltmedizin, Verbraucherschutz / Boden- und Lufthygiene (Berlin) Institut für Wasser-. - (2019), Heft 2, Seite 7