Person: Lange, Rosa
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Veröffentlichung Substitutes mimic the exposure behaviour of REACH regulated phthalates(2021) Apel, Petra; Kolossa-Gehring, Marike; Lange, Rosa; Lemke, Nora; Debiak, Malgorzata; Murawski, Aline; Weber, TillThe population is constantly exposed to potentially harmful substances present in the environment, including inter alia food and drinking water, consumer products, and indoor air. Human biomonitoring (HBM) is a valuable tool to determine the integral, internal exposure of the general population, including vulnerable subgroups, to provide the basis for risk assessment and policy advice. The German HBM system comprises of five pillars: (1) the development of suitable analytical methods for new substances of concern, (2) cross-sectional population-representative German Environmental Surveys (GerES), (3) time trend analyses using archived samples from the Environmental Specimen Bank (ESB), (4) the derivation of health-based guidance values as a risk assessment tool, and (5) transfer of data into the European cooperation network HBM4EU. The goal of this paper is to present the complementary elements of the German HBM system and to show its strengths and limitations on the example of plasticizers. Plasticizers have been identified by EU services and HBM4EU partners as priority substances for chemical policy at EU level. Using the complementary elements of the German HBM system, the internal exposure to classical phthalates and novel alternative plasticizers can be reliably monitored. It is shown that market changes, due to regulation of certain phthalates and the rise of substitutes, are rapidly reflected in the internal exposure of the population. It was shown that exposure to DEHP, DiBP, DnBP, and BBzP decreased considerably, whereas exposure to the novel substitutes such as DPHP, DEHTP, and Hexamoll®DINCH has increased significantly. While health-based guidance values for several phthalates (esp. DnBP, DiBP, DEHP) were exceeded quite often at the turn of the millennium, exceedances today have become rarer. Still, also the latest GerES reveals the ubiquitous and concurrent exposures to many plasticizers. Of concern is that the youngest children showed the highest exposures to most of the investigated plasticizers and in some cases their levels of DiBP and DnBP still exceeded health-based guidance values. Over the last years, mixture exposures are increasingly recognized as relevant, especially if the toxicological modes of action are similar. This is supported by a cumulative risk assessment for four endocrine active phthalates which confirms the still concerning cumulative exposure in many young children. Given the adverse health effects of some phthalates and the limited toxicological knowledge of substitutes, exposure reduction and surveillance are needed on German and EU-level. Substitutes need to be monitored, to intervene if exposures are threatening to exceed acceptable levels, or if new toxicological data question their appropriateness. It is strongly recommended to reconsider the use of plastics and plasticizers. © 2021 Published by Elsevier GmbH.Veröffentlichung Deutsche Umweltstudie zur Gesundheit von Kindern und Jugendlichen 2014-2017 (GerES V)(Umweltbundesamt, 2023) Hahn, Domenica; Kolossa-Gehring, Marike; Lange, Rosa; Lemke, Nora; Murawski, Aline; Peisker, Jasmin; Debiak, Malgorzata; Rucic, Enrico; Zimmermann, Philipp; David, Madlen; Gerofke, Antje; Weber, Till; Pack, Kim LauraIn der Deutschen Umweltstudie zur Gesundheit (GerES) wird die Schadstoff-Belastung der Bevölkerung repräsentativ für die Menschen in Deutschland erhoben. In der fünften Erhebung, GerESV (2014-2017), wurden 2.294 Kinder und Jugendliche im Alter von 3 bis 17 Jahren aus 167 Orten in ganz Deutschland untersucht. GerES V ist eine bevölkerungsrepräsentative Querschnittstudie und wurde in enger Kooperation mit der "Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland" (KiGGS Welle 2) des Robert-Koch-Instituts durchgeführt. Im Human-Biomonitoring (HBM) von GerESV wurden 107 verschiedene Substanzen im Blut bzw. Urin der Teilnehmenden gemessen. Der vorliegende Bericht fasst die HBM-Ergebnisse von GerESV zusammen. Bei Vorliegen entsprechender Beurteilungswerte wird eine gesundheitliche Bewertung vorgenommen. Der Bericht gibt einen Überblick über die Abläufe der Datenerhebung und die chemisch-analytischen und statistischen Methoden. Die wichtigsten Ergebnisse zu Belastungsquellen und -pfaden sowie besonders belasteten Bevölkerungsgruppen sind zusammengefasst und in aggregierter Form tabellarisch präsentiert. Für jede untersuchte Substanz werden außerdem die Quellen, die toxikologischen Eigenschaften und aktuellen Regulationen aufgeführt. Die bisherige Nutzung der Daten aus GerES V für Politik- und Öffentlichkeitsarbeit sowie in internationalen Kooperationen ist ebenfalls dargelegt. Quelle: ForschungsberichtVeröffentlichung Corrigendum to "Substitutes mimic the exposure behaviour of REACH regulated phthalates - A review of the German HBM system on the example of plasticizers"(2022) Apel, Petra; Kolossa-Gehring, Marike; Lange, Rosa; Lemke, Nora; Debiak, Malgorzata; Murawski, Aline; Weber, Till