Person: Fiddicke, Ulrike
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Ulrike
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Veröffentlichung A pilot study on the feasibility of European harmonized Human Biomonitoring: Strategies towards a common approach, challenges and opportunities(2015) Casteleyn, Ludwine; Dumez, Birgit; Becker, Kerstin; Den Hond, Elly; Schoeters, Greet; Castaño, Argelia; Koch, Holger Martin; Angerer, Jürgen; Esteban, Marta; Exley, Karen; Sepai, Ovnair; Bloemen, Louis; Fiddicke, Ulrike; Horvath, Milena; Knudsen, Lisbeth E.; Joas, Anke; Joas, Reinhard; Biot, Pierre; Koppen, C.; Dewolf, M.-C.; Katsonouri, Andromachi; Hadjipanayis, Adamos; Cerna, Milena; Krskova, A.; Kolossa-Gehring, Marike; Nielsen, Jeanette K.S.; Jensen, J.F.; Rudnai, Peter; Közepesy, S.; Mulcahy, M.F.R.; Mannion, R.; Gutleb, Arno C.; Fischer, M.E.; Ligocka, Danuta; Jakubowski, M.; Reis, M.Fátima; Namorado, S.; Lupsa, Ioana-Rodica; Schwedler, Gerda; Gurzau, Anca ElenaIn 2004theEuropeanCommissionandMemberStatesinitiatedactivitiestowardsaharmonizedap-
proach forHumanBiomonitoringsurveysthroughoutEurope.Themainobjectivewastosustainen-
vironmental healthpolicybybuildingacoherentandsustainableframeworkandbyincreasingthe
comparability ofdataacrosscountries.Apilotstudy totestcommonguidelinesforsettingupsurveys
wasconsideredakeystepinthisprocess.Throughabottom-upapproachthatincludedallstakeholders,
a jointstudyprotocolwaselaborated.
FromSeptember2011tillFebruary2012,17Europeancountriescollecteddatafrom1844mother-
child pairsintheframeofDEMOnstrationofastudytoCoordinateandPerformHumanBiomonitoring
on aEuropeanScale(DEMOCOPHES). Mercury inhairandurinarycadmiumandcotininewereselected
as biomarkersofexposurecoveredbysufficient analyticalexperience.PhthalatemetabolitesandBi-
sphenol Ainurinewereaddedtotakeintoaccountincreasingpublicandpoliticalawarenessfor
emerging typesofcontaminantsandtotestlessadvancedmarkers/markerscoveredbylessanalytical
experience.Extensiveeffortstowardschemo-analyticalcomparabilitywereincluded.
The pilotstudyshowed thatcommonapproachescanbefoundinacontextofconsiderablediffer-
ences withrespecttoexperienceandexpertize,socio-culturalbackground,economicsituationandna-
tional priorities.ItalsoevidencedthatcomparableHumanBiomonitoringresultscanbeobtainedinsuch
context.AEuropeannetworkwasbuilt,exchanging information,expertise andexperiences,andpro-
viding trainingonallaspectsofasurvey.Akeychallengewas finding therightbalancebetweenarigid
structure allowingmaximalcomparabilityanda flexibleapproachincreasingfeasibilityandcapacity
building. NextstepsinEuropeanharmonizationinHumanBiomonitoringsurveysincludetheestab-
lishment ofajointprocessforprioritizationofsubstancestocoverandbiomarkerstodevelop,linking
biomonitoring surveyswithhealthexaminationsurveysandwithresearch,andcopingwiththediverse
implementations ofEUregulationsandinternationalguidelineswithrespecttoethicsandprivacy.
©2014ElsevierInc.Allrightsreserved.Veröffentlichung New human biomonitoring methods for chemicals of concern̶the German approach to enhance relevance(2017) Fiddicke, Ulrike; Leng, Gabriele; Kolossa-Gehring, Marike; Angerer, Jürgen; Wolz, BirgitVeröffentlichung Interpreting biomarker data from the COPHES-DEMOCOPHES twin projects: Using lifestyle and environmental data to understand biomarker differences among countries(2013) Den Hond, Elly; Govarts, Eva; Koppen, Gudrun; Willems, Hanny; Joas, Reinhard; Casteleyn, Ludwine; Joas, Anke; Biot, Pierre; Aerts, Dominique; Angerer, Jürgen; Berglund, Marika; Bloemen, Louis; Castaño, Argelia; Fiddicke, Ulrike; Crettaz, Pierre; Esteban, Marta; Exley, Karen; Fabianova, Eleonora; Fischer, Marc; Gutleb, Arno Christian; Hadjipanayis, Adamos; Halzlova, Katarina; Horvat, Milena; Jakubowski, Marek; Katsonouri, Andromachi; Kolossa-Gehring, Marike; Koch, Holger; Krskova, Andrea; Lehmann, Andreas; Ligocka, Danuta; Lupsa, Ioana-Rodica; Mazej, Darja; Mulcahy, Maurice; Namorado, Sónia; Nielsen, Jeanette; Schwedler, GerdaIn 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed a first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, cadmium, cotinine and certain phthalate metabolites were measured in urine, and total mercury in hair samples. The presentation provides an overview of the analyses that studied whether it was feasible to interpret the observed differences in biomarker values among different countries, using external databases on environmental quality and lifestyle.
Despite the fact that harmonised biomonitoring data was available from 17 different European countries, the assessment was hampered by a lack of consistent data on lifestyle and environmental quality. This implied that most analyses could only be performed for about half to two thirds of the participating countries. Nonetheless, it was feasible to relate aggregated fish consumption data to mercury in hair, to relate the strength of anti-smoking legislation to urinary cotinine levels, and to find a borderline significant relationship between cadmium levels in air or food and urinary cadmium levels across DEMOCOPHES countries. However, the challenge to integrate environmental exposure and lifestyle data with biomarker data is to have data available on a similar geographical resolution and therefore remains a pitfall for human biomonitoring to achieve its true potential for evidence-based policy making.
With many thanks to the COPHES consortium funded by DG RTD under FP7 and DEMOCOPHES co-funded under Life+, as well as the Ministries of the DEMOCOPHES countries, for the support. www.eu-hbm.infoRoel Smolders, et al.: Interpreting biomarker data from the COPHES-DEMOCOPHES twin projects: Using lifestyle and environmental data to understand biomarker differences among countries. In: Abstracts / The 9thInternational Symposium on Biological Monitoring in Occupational and Environmental Health. 2013, Manchester, S. 33
Veröffentlichung Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach(2017) Fiddicke, Ulrike; Ißleb, Sissy; Kolossa-Gehring, Marike; Schwedler, Gerda; Seiwert, MargareteHuman biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries. In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6Ń11 year old children and their mothers in an urban and a rural region. Seventeen European countries simultaneously conducted this cross-sectional DEMOCOPHES feasibility study. The German study population was taken in the city of Bochum and in the Higher Sauerland District, comprising 120 mother-child pairs. In the present paper features of the study implementation are presented. German exposure concentrations of the pollutants are reported and compared with European average concentrations from DEMOCOPHES and with those measured in the representative German Environmental Survey (GerES IV). German DEMOCOPHES concentrations for mercury and cotinine were lower than the European average. However, 47% of the children were still exposed to environmental tobacco smoke (ETS) outside their home, which gives further potential for enhancing protection of children from ETS. Compared with samples from the other European countries German participating children had lower concentrations of the phthalate metabolites MEP and of the sum of 3 DEHP-metabolites (MEHP, 5OH-MEHP and 5oxo-MEHP), about the same concentrations of the phthalate metabolites MBzP and MiBP and higher concentrations of the phthalate metabolite MnBP. 2.5% of the German children had concentrations of the sum of 4 DEHP-metabolites and 4.2% had concentrations of MnBP that exceeded health based guidance values, indicating reasons for concern. Continuous HBM is necessary to track changes of pollutant exposure over time. Therefore Germany will continue to cooperate on the harmonisation of European human biomonitoring to support the chemicals regulation with the best possible exposure data to protect Europe's people against environmental health risks. Quelle: http://www.sciencedirect.comVeröffentlichung New specific and sensitive biomonitoring methods for chemicals of emerging health relevance(2017) Leng, Gabriele; Fiddicke, Ulrike; Gries, Wolfgang; Kolossa-Gehring, MarikeIn this publication the challenges to cope for the aim to obtain innovative biomonitoring methods in our laboratory are visualized for di(2-propylheptyl)phthalate, 2-mercaptobenzothiazole, 3,5-di-tert-butyl-4-hydroxytoluene, 4-nonylphenol, 4-tert-octylphenol, 3-(4-methylbenzylidene)camphor, 4,4'-methylene diphenyl diisocyanate, and Hexabromocyclododecane. For these substances new specific markers were explored based on animal or human kinetic data with urine being the preferred matrix compared to blood. The determination of these markers was complex in all cases, because the sample preparation as well as the detection by high performance liquid chromatography, capillary gas chromatography coupled to tandem mass spectrometers or high resolution mass spectrometry should enable the lowest possible detection limit by use of minimal biological sample volumes. To get a first hint of a possible background level, the analytical methods were applied to urine samples of about 40 persons for each chemical. For Di(2-propylheptyl)phthalate and 2-Mercaptobenzothiazole first results are presented from population biomonitoring. Quelle: http://www.sciencedirect.comVeröffentlichung Human biomonitoring as a tool to support chemicals regulation in the European Union(2017) Ganzleben, Catherine; Antignac, Jean-Philippe; Barouki, Robert; Fiddicke, Ulrike; Kolossa-Gehring, Marike