Person: Höflich, Conny
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Veröffentlichung Management of patients with seasonal allergic rhinitis: Diagnostic consideration of sensitization to non-frequent pollen allergens(2021) Balakirski, Galina; Hajdu, Zuzanna; Höflich, Conny; Mücke, Hans-Guido; Straff, WolfgangBackground Diagnosis of pollen allergies is mainly based on test allergens for skin prick testing. In the minimum battery of test inhalant allergens recommended by the Global Allergy and Asthma European Network 10 pollen allergens are included. Complementary other pollen allergens may need to be considered; however, respective awareness may not always be granted. Furthermore, at least in Germany, the situation may be even more complicated by the fact that test allergens need regulatory approval. A decline in commercially available test allergens may result in a diagnostic gap regarding patients with non-frequent allergies. How many patients with non-frequent pollen allergies would be affected by this gap? The data presented here partly answer this question. Methods The study consisted of a descriptive and an analytical part. In the descriptive part, sensitization to frequent pollen allergens (alder, hazel, birch, sweet grasses; according to the German Therapy Allergen Ordinance) and to respective non-frequent pollen allergens (cypress, Japanese cedar, ash, plane tree, olive, Bermuda grass, wall pellitory, plantain, goosefoot, mugwort, ragweed, and saltwort) was measured in adult patients with physician-diagnosed allergic rhinitis from two German federal states, namely North-Rhine Westphalia (n = 360) and Bavaria (n = 339), using skin prick testing and/or ISAC technology. Furthermore, respective regional pollen data were assessed. In the analytical part, sensitization data were correlated with each other and with anamnestic data on symptom periods. Results Sensitization to frequent pollen allergens ranged from 45% (sIgE to Aln g 1/Alder, NRW) to 72% (prick test reactivity to birch, NRW). Sensitization to non-frequent pollen allergens ranged from 0% (sIgE to Amb a 1/ragweed, NRW) to 41% (prick test reactivity to olive, Bavaria). Sensitization data partly correlated with each other and in connection with symptom periods showed a partly similar seasonal pattern as pollen data. Conclusions Sensitization to non-frequent pollen allergens have to be considered when examining patients with respective seasonal symptoms, and test (and respective therapy) allergens for non-frequent pollen allergies need to be available. Further prerequisites for adequate patient management would be a nationwide pollen monitoring system giving continuous pollen data and a systematic sensitization monitoring at patient level. © The Authors.Veröffentlichung Management of patients with seasonal allergic rhinitis: Diagnostic consideration of sensitization to non-frequent pollen allergens(2021) Balakirski, Galina; Höflich, Conny; Mücke, Hans-Guido; Straff, WolfgangVeröffentlichung Management of patients with seasonal allergic rhinitis: diagnostic consideration of sensitization to non-frequent pollen allergens(2022) Balakirski, Galina; Höflich, Conny; Mücke, Hans-Guido; Straff, Wolfgang; Deutschland. Umweltbundesamt. Fachbereich II - Gesundheitlicher Umweltschutz, Schutz der ÖkosystemeBackground Diagnosis of pollen allergies is mainly based on test allergens for skin prick testing. In the minimum battery of test inhalant allergens recommended by the Global Allergy and Asthma European Network ten pollen allergens are included. Complementary, other pollen allergens may need to be considered, however, respective awareness may not always be granted. Furthermore, at least in Germany, the situation may be even more complicated by the fact that test allergens need regulatory approval. A decline of commercially available test allergens may result in a diagnostic gap regarding patients with non-frequent allergies. How many patients with non-frequent pollen allergies would be affected by this gap? The data presented here partly answer this question. Method The study consisted of a descriptive and an analytical part. In the descriptive part, sensitization to frequent pollen allergens (alder, hazel, birch, sweet grasses; according to the German Therapy Allergen Ordinance) and to respective non-frequent pollen allergens (cypress, Japanese cedar, ash, plane tree, olive, Bermuda grass, wall pellitory, plantain, goosefoot, mugwort, ragweed and saltwort) were measured in adult patients with physician-diagnosed allergic rhinitis from two German federal states, namely North-Rhine Westphalia (n=360) and Bavaria (n=339), using skin prick testing and/or ISAC technology. Furthermore, respective regional pollen data were assessed. In the analytical part, sensitization data were correlated with each other and with anamnestic data on symptom periods. Results Sensitization to frequent pollen allergens ranged from 45 % (sIgE to Aln g 1/alder, NRW) to 72 % (prick test reactivity to birch, NRW). Sensitization to non-frequent pollen allergens ranged from 0 % (sIgE to Amb a 1/ragweed, NRW) to 41 % (prick test reactivity to olive, Bavaria). Sensitization data partly correlated with each other and in connection with symptom periods showed a partly similar seasonal pattern as pollen data. Conclusion Sensitization to non-frequent pollen allergens have to be considered when examining patients with respective seasonal symptoms, and test (and respective therapy) allergens for non-frequent pollen allergies need to be available. Further prerequisites for adequate patient management would be a nationwide pollen monitoring system giving continuous pollen data and a systematic sensitization monitoring at patient level. Quelle: www.eaaci2022.process.y-congress.comVeröffentlichung Auswirkungen des Klimawandels auf allergische Erkrankungen in Deutschland(2023) Bergmann, Karl-Christian; Brehler, Randolf; Endler, Christina; Höflich, ConnyHintergrund: Allergische Erkrankungen, vor allem Inhalationsallergien, haben ein epidemisches Ausmaß erreicht, und Umweltfaktoren spielen eine wichtige Rolle bei ihrer Entstehung. Der Klimawandel beeinflusst Auftreten, Häufigkeit und Schwere allergischer Erkrankungen. Methode: Die Inhalte dieses Artikels wurden durch die Autorinnen und Autoren ausgewählt und entsprechend ihren Expertisen nach dem aktuellen Wissensstand kapitelweise erarbeitet. Die Kapitel wurden anschließend mit allen Autorinnen und Autoren diskutiert und abgestimmt. Ergebnisse: Der Artikel beleuchtet direkte und indirekte Effekte des Klimawandels auf Allergien. Er geht näher auf Zusammenhänge zwischen Klimawandel und (neuen) Pollenallergenen sowie (neuen) beruflichen Inhalationsallergenen ein, erläutert Auswirkungen des Klimawandels auf das Krankheitsbild der Neurodermitis, geht auf Zusammenhänge zwischen Luftschadstoffen und Allergien ein und informiert über das Phänomen des Gewitterasthmas. Schlussfolgerungen: Es besteht unter anderem Handlungsbedarf für die Bereiche Pollen- und Schimmelpilzsporenmonitoring, Allergie- und Sensibilisierungsmonitoring, Städteplanung unter allergologischen Gesichtspunkten und Veränderungen der Arbeitswelt. Quelle: ArtikelVeröffentlichung Pollenassoziierte allergische Erkrankungen in Zeiten des Klimawandels(2019) Höflich, ConnyAllergien, insbesondere pollenassoziierte Allergien der Atemwege, sind weltweit verbreitet und nehmen weiter zu. Den Klima-wandel verursachende beziehungsweise kennzeichnende Veränderungen, wie der Anstieg der atmosphärischen Kohlendioxidkonzentration und der Erdoberflächentemperatur, führen sehr wahrscheinlich zu einer Zunahme der Pollenbelastung und damit zu einer Zunahme allergischer Pollensensibilisierungen und pollenassoziierter allergischer Erkrankungen. Im Jahr 2014 wurde in dieser Zeitschrift ausführlicher über diese möglichen Zusammenhänge berichtet. Im Jahr 2017 hielt die Autorin auf dem Deutschen Allergiekongress am Beispiel der Pollen der Beifuß-Ambrosie einen Plenarvortrag zu diesem Thema. Der folgende Beitrag fasst die Inhalte des Vortrags zusammen. Verlagsinformation