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Veröffentlichung Effects of anticoagulant rodenticide poisoning on spatial behavior of farm dwelling Norway rats(2021) Walther, Bernd; Ennen, Hendrik; Geduhn, Anke; Schlötelburg, AnnikaCommensal rodent species cause damage to crops and stored products, they transmit pathogens to people, live-stock and pets and threaten nativeflora and fauna. Tominimize such adverse effects, commensal rodentsare pre-dominantly managed with anticoagulant rodenticides (AR) that can be transferred along the food chain. Wetested the effect of the uptake of the AR brodifacoum (BR) by Norway rats (Rattus norvegicus) on spatial behaviorbecause this helps to assess the availability of dead rats and residual BR to predators and scavengers. BR was de-livered by oral gavage or free-fed bait presented in bait stations. Rats were radio-collared to monitor spatial be-havior. BR residues in rat liver tissue were analyzed using liquid chromatography coupled with tandem massspectrometry. Norway rats that had consumed BR decreased distances moved and had reduced home rangesize. Treatment effects on spatial behavior seemed to set in rapidly. However, there was no effect on habitat pref-erence. Ninety-two percent of rats that succumbed to BR died in well-hidden locations, where removal by scav-enging birds and large mammalian scavengers is unlikely. Rats that ingested bait from bait stations had 65% higher residue concentrations than rats that died from dosing with two-fold LD50.Thissuggestsanoverdosingin rats that are managed with 0.0025% BR. None of the 70 BR-loaded rats was caught/removed by wild preda-tors/scavengers before collection of carcasses within 5-29 h. Therefore, and because almost all dead rats diedin well-hidden locations, they do not seem to pose a significant risk of AR exposure to large predators/scavengers at livestock farms. Exposure of large predators may originate from AR-poisoned non-target small mammals. Thefew rats that died in the open are accessible and should be removed in routine searches during and after the ap-plication of AR bait to minimize transfer of AR into the wider environment. © 2021 The Authors. Published by Elsevier B.V.Veröffentlichung Comprehensive screening of polar emerging organic contaminants including PFASs and evaluation of the trophic transfer behavior in a freshwater food web(2022) Fu, Qiuguo; Meyer, Corina; Koschorreck, Jan; Patrick, MichaelBioaccumulation and trophic transfer of persistent legacy contaminants have been intensively characterized, but little is known on the contaminants of emerging concern (CECs) in freshwater food webs. Herein, we comprehensively screened CECs with a focus on polar substances and further evaluated their trophic transfer behavior in selected items from the food web of Lake Templin, Germany. Weselected one plankton, two mussel, and nine fish samples covering three trophic levels. With an effective multi-residue sample preparation method and high-resolution mass spectrometry-based target, suspect, and non-target screening, we characterized 477 targets and further screened unknown features in complex biota matrices. Of the 477 targets, 145 were detected and quantified in at least one species (0.02-3640 ng/g, dry weight). Additionally, the suspect and non-target analysis with experimental mass spectra libraries and in silico techniques (MetFrag and SIRIUS4/CSI:FingerID) enabled further identification of 27 unknown compounds with 19 confirmed by reference standards. Overall, the detected compounds belong to a diverse group of chemicals, including 71 pharmaceuticals, 27 metabolites, 26 pesticides, 16 per- and polyfluoroalkyl substances (PFASs), 4 plasticizers, 3 flame retardants, 11 other industrial chemicals and 14 others. Moreover, we determined the trophic magnification factor (TMF) of 34 polar CECs with >80% detection frequency, among which 6 PFASs including perfluorooctane sulfonic acid (PFOS), perfluorodecanoic acid (PFDA), perfluorohexane sulfonic acid (PFHxS), perfluorotridecanoic acid (PFTrA), perfluorotetradecanoic acid (PFTeA), and perfluoroundecanoic acid (PFUnA), exhibited biomagnification potential (TMF =1.8 - 4.2, p < 0.05), whereas 5 pharmaceuticals (phenazone, progesterone, venlafaxine, levamisole, and lidocaine) and 1 personal care product metabolite (galaxolidone) showed biodilution potential (TMF = 0.4 - 0.6, p < 0.05). © 2022 The Authors