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Veröffentlichung New Approach to weight-of-evidence assessment of ecotoxicological effects in regulatory decision-making(2017) Hall, A. Tilghman; Belanger, Scott E.; Guiney, Pat D.; Maack, GerdVeröffentlichung Evaluating the credibility of histopathology data in environmental endocrine toxicity studies(2017) Wolf, Jeffrey C.; Maack, GerdVeröffentlichung Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances(2017) Matthiessen, Peter; Ankley, Gerald T.; Biever, Ronald C.; Maack, GerdVeröffentlichung Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances(2017) Coady, Katherine K.; Biever, Ronald C.; Denslow, Nancy N.; Maack, GerdVeröffentlichung Environmental Risk Assessment of Pharmaceuticals in Europe(2019) Maack, GerdVeröffentlichung Improving environmental risk assessments of chemicals: Steps towards evidence-based ecotoxicology(2019) Martin, Olwenn V.; Adams, Julie; Beasley, Amy; Maack, GerdVeröffentlichung Emerging investigator series: use of behavioural endpoints in the regulation of chemicals(2020) Ågerstrand, Marlene; Arnold, Kathryn; Balshine, Sigal; Maack, GerdInterest in behavioural ecotoxicology is growing, partly due to technological and computational advances in recording behaviours but also because of improvements of detection capacity facilitating reporting effects at environmentally relevant concentrations. The peer-reviewed literature now contains studies investigating the effects of chemicals, including pesticides and pharmaceuticals, on migration, dispersal, aggression, sociability, reproduction, feeding and anti-predator behaviours in vertebrates and invertebrates. To understand how behavioural studies could be used in regulatory decision-making we: (1) assessed the legal obstacles to using behavioural endpoints in EU chemicals regulation; (2) analysed the known cases of use of behavioural endpoints in EU chemicals regulation; and (3) provided examples of behavioural endpoints of relevance for population level effects. We conclude that the only legal obstacle to the use of behavioural endpoints in EU chemicals regulation is whether an endpoint is considered to be relevant at the population level or not. We also conclude that ecotoxicity studies investigating behavioural endpoints are occasionally used in the EU chemicals regulation, and underscore that behavioural endpoints can be relevant at the population level. To improve the current use of behavioural studies in regulatory decision-making contribution from all relevant stakeholders is required. We have the following recommendations: (1) researchers should conduct robust, well-designed and transparent studies that emphasize the relevance of the study for regulation of chemicals; (2) editors and scientific journals should promote detailed, reliable and clearly reported studies; (3) regulatory agencies and the chemical industry need to embrace new behavioural endpoints of relevance at the population level. © The Royal Society of Chemistry 2020Veröffentlichung Assessment of Endocrine disruptor under European regulations(2020) Maack, Gerd; Arning, Jürgen; Frische, Tobias; Kehrer-Berger, Anja; Mordziol, ChristophVeröffentlichung The role of behavioral ecotoxicology in environmental protection(2021) Ford, Alex; Ågerstrand, Marlene; Brooks, Bryan W.; Duquesne, Sabine; Sahm, René; Gergs, René; Jacob, Stefanie; Maack, Gerd; Mohr, SilviaFor decades, we have known that chemicals affect human and wildlife behavior. Moreover, due to recent technological and computational advances, scientists are now increasingly aware that a wide variety of contaminants and other environmental stressors adversely affect organismal behavior and subsequent ecological outcomes in terrestrial and aquatic ecosystems. There is also a groundswell of concern that regulatory ecotoxicology does not adequately consider behavior, primarily due to a lack of standardized toxicity methods. This has, in turn, led to the exclusion of many behavioral ecotoxicology studies from chemical risk assessments. To improve understanding of the challenges and opportunities for behavioral ecotoxicology within regulatory toxicology/risk assessment, a unique workshop with international representatives from the fields of behavioral ecology, ecotoxicology, regulatory (eco)toxicology, neurotoxicology, test standardization, and risk assessment resulted in the formation of consensus perspectives and recommendations, which promise to serve as a roadmap to advance interfaces among the basic and translational sciences, and regulatory practices. © 2021 The AuthorsVeröffentlichung Comment on environmental quality standards for diclofenac derived under the European Water Framework Directive(2022) Maack, Gerd; Äystö, Lauri; Carere, MarioLeverett et al. commented on the Environmental quality standard (EQS) for diclofenac derived under the European Water Framework Directive [Leverett et al. (2021) Environ Sci Eur 33: 133 https:// doi. org/ 10. 1186/ s12302- 021- 00574-z]. They postulated that the derivation of the EQS value for diclofenac is not conducted according to the EQS Technical Guidance, but rather using data of poor reliability and relevance. Consequently, the authors suggested using their alternative derived value instead. It is to be noted that the process for the EQS derivation for diclofenac is still ongoing and not finalized, and that as a consequence, any critical analysis is very premature. In general, within the current European Commission process, EQS values proposals are derived by expert groups led by the Joint Research Centre. In the specific case for diclofenac, Leverett et al. have also been actively involved as experts. This response to Leverett et al. (2021) aims to clarify the reasoning behind the proposal from a scientific point of view and to express our concern for the lack of transparency of their position in the statement of competing interests. Indeed, the authors did not disclose their participation in the expert group for deriving the diclofenac EQS value, nor that they have direct and indirect ties to a company that markets diclofenac in Europe, Glaxo Smith & Kline plc (GSK). This amounts to a significant conflict of interest and leads to disinformation to the reader. © The Author(s) 2022