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Veröffentlichung Data for Policy - Human biomonitoring's contribution to evidence-informed environmental health policy-making(North Carolina, 2017) Conrad, André; Rucic, Enrico; Schulz, Christine; Schwedler, Gerda; Rüther, Maria; Apel, Petra; Schmied-Tobies, Maria Irene Hilde; Weber, Till; Kolossa-Gehring, MarikeVeröffentlichung DINCH Exposure in Germany has become omnipresent and is further increasing - urinary data from the German Environmental Specimen Bank (1999-2017)(2018) Koch, Holger Martin; Kasper-Sonnenberg, Monika; Weber, Till; Apel, Petra; Kolossa-Gehring, MarikeVeröffentlichung From zero to one-hundred in 15 years(2018) Koch, Holger Martin; Kasper-Sonnenberg, Monika; Weber, Till; Apel, Petra; Kolossa-Gehring, MarikeVeröffentlichung German Environmental Specimen Bank (ESB)(2017) Weber, Till; Koch, Holger M.; Conrad, André; Rüther, Maria; Apel, Petra; Kolossa-Gehring, MarikeVeröffentlichung New human biomonitoring methods for chemicals of interest(2014) Fiddicke,Ulrike; Kolossa-Gehring, Marike; Apel, Petra; Schröter-Kermani, Christa; Bader, Michael; Leng, Gabriele; Koch, Holger M.Introduction The German initiative to develop new human biomonitoring (HBM) methods forsubstances of interest is a cooperation of the Federal Ministry for the Environment, Nature Conservation,Building and Nuclear Safety (BMUB) and the German Chemical Industry Association (VCI) which started in2010. Emphasis is placed on substances either with potential health relevance or for which an exposure of the
general population can be assumed. Methods After identification of relevant chemicals by an expert panel HBMmethods are developed and first applied to about 40 non occupationally exposed persons. The analyticalmethods are cross-validated by the working group ´Analyses in biological Materials of the German ResearchFoundation (DFG) and published together with pilot-test results in international, peer-reviewed journals. ResultsNew HBM methods for methylenediphenyl diisocyanate (MDI ), used in polyurethane and adhesives, thevulcanization accelerator 2-mercaptobenzothiazole (2-MBT), the plasticizer alternatives Hexamoll® DINCH anddi-2-propylheptyl phthalate (DPHP), the alkylphenols 4-tert-octylphenol and 4-nonylphenol and the technicalsolvents N-methyl- and N-ethyl-2-pyrrolidone (NMP/NEP) have already been developed and applied. For someof these chemicals a considerable background exposure seems to be unlikely (e.g. MDI), for other substances(e.g. NMP/NEP) a ubiquitous background was detected. For DINCH and DPHP, trends of increasing exposurewere observed in urine samples from the German Environmental Specimen Bank, mirroring the marketintroduction of the substances. The relevance of the findings needs to be assessed by toxicologically derivedHuman Biomonitoring Values (Biomonitoring Equivalents) and by population representative studies.Consequently, we plan to include these substances in the 5th German Environmental Survey. The results willcontribute to a realistic exposure and risk assessment for these "newŁ chemicals in German children.
Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstract Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S.159Veröffentlichung New human biomonitoring methods for chemicals of interest(2013) Fiddicke,Ulrike; Kolossa-Gehring, Marike; Apel, Petra; Leng, Gabriele; Koch, Holger M.Veröffentlichung The German Human Biomonitoring Commission - Reference and HBM values(2016) Apel, Petra; Angerer, Jürgen; Kolossa-Gehring, Marike; Wilhelm, Michael