Person: Valtanen, Kerttu
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Veröffentlichung Inhalte des neuen UBA Schimmelleitfadens(2017) Valtanen, KerttuVeröffentlichung Holi colours contain PM10 and can induce pro-inflammatory responses(2016) Bach, Sabine; Bossmann, Katrin; Heinze, Rita; Höflich, Conny; Neumann, Anett; Straff, Wolfgang; Süring, Katrin; Valtanen, KerttuBackground
At Holi festivals, originally celebrated in India but more recently all over the world, people throw coloured powder (Holi powder, Holi colour, Gulal powder) at each other. Adverse health effects, i.e. skin and ocular irritations as well as respiratory problems may be the consequences. The aim of this study was to uncover some of the underlying mechanisms.
Methods
We analysed four different Holi colours regarding particle size using an Electric field cell counting system. In addition, we incubated native human cells with different Holi colours and determined their potential to induce a pro-inflammatory response by quantifying the resulting cytokine production by means of ELISA (Enzyme Linked Immunosorbent Assay) and the resulting leukocyte oxidative burst by flow cytometric analysis. Moreover, we performed the XTT (2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide) and Propidium iodide cytotoxicity tests and we measured the endotoxin content of the Holi colour samples by means of the Limulus Amebocyte Lysate test (LAL test).
Results
We show here that all tested Holi colours consist to more than 40 % of particles with an aerodynamic diameter smaller than 10 ìm, so called PM10 particles (PM, particulate matter). Two of the analysed Holi powders contained even more than 75 % of PM10 particles.
Furthermore we demonstrate in cell culture experiments that Holi colours can induce the production of the pro-inflammatory cytokines TNF-á(Tumor necrosis factor-á), IL-6 (Interleukine-6) and IL-1â(Interleukine-1â). Three out of the four analysed colours induced a significantly higher cytokine response in human PBMCs (Peripheral Blood Mononuclear Cells) and whole blood than corn starch, which is often used as carrier substance for Holi colours. Moreover we show that corn starch and two Holi colours contain endotoxin and that certain Holi colours display concentration dependent cytotoxic effects in higher concentration. Furthermore we reveal that in principle Holi colours and corn starch are able to generate an oxidative burst in human granulocytes and monocytes. In Holi colour 1 we detected a fungal contamination.
Conclusions
Some of the observed unwanted health effects of Holi colours might be explained by the high content of PM10 particles in conjunction with the possible induction of a pro-inflammatory response and an oxidative leukocyte burst.
Quelle: http://occup-med.biomedcentral.comVeröffentlichung BSS-Guideline "Testing of mould detection dogs"(2017) Lorenz, Wolfgang; Hernstadt, Charlotte; Kolek, Birgit; Valtanen, Kerttu; Bundesverband Schimmelpilzsanierung e.V.Veröffentlichung Schimmel in der Wohnung(2017) Valtanen, KerttuVeröffentlichung Gefahr durch Schimmel(2017) Valtanen, Kerttu; Rundfunk Berlin-BrandenburgBewohner gehen mitunter zu leichtsinnig mit Schimmel um. Da werden befallene Stellen im Do-it-yourself-Verfahren oberflächlich entfernt oder durch einfaches Überstreichen kaschiert. Auch Anti-Schimmel-Sprays, wie sie in der Werbung angepriesen werden, sind beliebt. Fachleute raten von solchen Maßnahmen dringend ab, weil damit die Ursache nicht beseitigt wird und weil die Schimmelpilze in der Regel auch in tiefere Schichten eingedrungen sind. Manche Leute machen auch den Fehler und warten zu lange, bis sie den Schimmel melden. Quelle: https://www.rbb-online.de/Veröffentlichung Schadstoffe im Innenraum - aktuelle Handlungsfelder(2018) Birmili, Wolfram; Kolossa-Gehring, Marike; Debiak, Malgorzata; Salthammer, Tunga; Valtanen, KerttuVeröffentlichung Saksan ympäristölaitoksen (UBA) uudistettu homesuositus(2018) Valtanen, KerttuVeröffentlichung Möglichkeiten und Grenzen der gesundheitlichen Bewertung von Schimmelexpositionen im Innenraum(2017) Wiesmueller, Gerhard A.; Heinzow, Birger; Szewzyk, Regine; Valtanen, Kerttu; Hurraß, JuliaVeröffentlichung Medical diagnostics for indoor mold exposure(2017) Hurraß, Julia; Heinzow, Birger; Aurbach, Ute; Szewzyk, Regine; Valtanen, KerttuVeröffentlichung Whole blood assay - a tool to assess the immunomodulatory activity of dust collected with different sampling methods from households with and without mold damage(2023) Böing, Margrietje; Liebers, Verena; Valtanen, Kerttu