Person: Rucic, Enrico
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Veröffentlichung Deutsche Umweltstudie zur Gesundheit von Kindern und Jugendlichen 2014-2017 (GerES V)(Umweltbundesamt, 2023) Hahn, Domenica; Kolossa-Gehring, Marike; Lange, Rosa; Lemke, Nora; Murawski, Aline; Peisker, Jasmin; Debiak, Malgorzata; Rucic, Enrico; Zimmermann, Philipp; David, Madlen; Gerofke, Antje; Weber, Till; Pack, Kim LauraIn der Deutschen Umweltstudie zur Gesundheit (GerES) wird die Schadstoff-Belastung der Bevölkerung repräsentativ für die Menschen in Deutschland erhoben. In der fünften Erhebung, GerESV (2014-2017), wurden 2.294 Kinder und Jugendliche im Alter von 3 bis 17 Jahren aus 167 Orten in ganz Deutschland untersucht. GerES V ist eine bevölkerungsrepräsentative Querschnittstudie und wurde in enger Kooperation mit der "Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland" (KiGGS Welle 2) des Robert-Koch-Instituts durchgeführt. Im Human-Biomonitoring (HBM) von GerESV wurden 107 verschiedene Substanzen im Blut bzw. Urin der Teilnehmenden gemessen. Der vorliegende Bericht fasst die HBM-Ergebnisse von GerESV zusammen. Bei Vorliegen entsprechender Beurteilungswerte wird eine gesundheitliche Bewertung vorgenommen. Der Bericht gibt einen Überblick über die Abläufe der Datenerhebung und die chemisch-analytischen und statistischen Methoden. Die wichtigsten Ergebnisse zu Belastungsquellen und -pfaden sowie besonders belasteten Bevölkerungsgruppen sind zusammengefasst und in aggregierter Form tabellarisch präsentiert. Für jede untersuchte Substanz werden außerdem die Quellen, die toxikologischen Eigenschaften und aktuellen Regulationen aufgeführt. Die bisherige Nutzung der Daten aus GerES V für Politik- und Öffentlichkeitsarbeit sowie in internationalen Kooperationen ist ebenfalls dargelegt. Quelle: ForschungsberichtVeröffentlichung Phthalate metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014-2017(2020) Conrad, André; Daniels, Anja; Kolossa-Gehring, Marike; Lange, Rosa; Rucic, Enrico; Schmied-Tobies, Maria Irene Hilde; Schulz, Christine; Schwedler, GerdaDuring the population representative German Environmental Survey of Children and Adolescents (GerES V, 2014-2017) 2256 first-morning void urine samples from 3 to 17 years old children and adolescents were analysed for 21 metabolites of 11 different phthalates (di-methyl phthalate (DMP), di-ethyl phthalate (DEP), butylbenzyl phthalate (BBzP), di-iso-butyl phthalate (DiBP), di-n-butyl phthalate (DnBP), di-cyclohexyl phthalate (DCHP), di-n-pentyl phthalate (DnPeP), di-(2-ethylhexyl) phthalate (DEHP), di-iso-nonyl phthalate (DiNP), di-iso-decyl phthalate (DiDP) and di-n-octyl phthalate (DnOP)). Metabolites of DMP, DEP, BBzP, DiBP, DnBP, DEHP, DiNP and DiDP were found in 97-100% of the participants, DCHP and DnPeP in 6%, and DnOP in none of the urine samples. Geometric means (GM) were highest for metabolites of DiBP (MiBP: 26.1 my g/L), DEP (MEP: 25.8 my g/L), DnBP (MnBP: 20.9 my g/L), and DEHP (cx-MEPP: 11.9 my g/L). For all phthalates but DEP, GMs were consistently higher in the 3-5 years old children than in the 14-17 years old adolescents. For DEHP, the age differences were most pronounced. All detectable phthalate biomarker concentrations were positively associated with the levels of the respective phthalate in house dust. In GerES V we found considerably lower phthalate biomarker levels than in the preceding GerES IV (2003-2006). GMs of biomarker levels in GerES V were only 18% (BBzP), 23% (MnBP), 23% (DEHP), 29% (MiBP) and 57% (DiNP) of those measured a decade earlier in GerES IV. However, some children and adolescents still exceeded health-based guidance values in the current GerES V. 0.38% of the participants had levels of DnBP, 0.08% levels of DEHP and 0.007% levels of DiNP which were higher than the respective health-based guidance values. Accordingly, for these persons an impact on health cannot be excluded with sufficient certainty. The ongoing and substantial exposure of vulnerable children and adolescents to many phthalates confirms the need of a continued monitoring of established phthalates, whether regulated or not, as well as of potential substitutes. With this biomonitoring approach we provide a picture of current individual and cumulative exposure developments and body burdens to phthalates, thus providing support for timely and effective chemicals policies and legislation. © 2020 The Authors. Published by Elsevier GmbH.Veröffentlichung Per- and polyfluoroalkyl substances in blood plasma - Results of the German Environmental Survey for children and adolescents 2014-2017 (GerES V)(2020) Conrad, André; Duffek, Anja; Kolossa-Gehring, Marike; Lange, Rosa; Rucic, Enrico; Schulte, Christoph; Wellmitz, JörgThe 5th cycle of the German Environmental Survey (GerES V) investigated the internal human exposure of children and adolescents aged 3-17 years in Germany to per- and polyfluoroalkyl substances (PFAS). The fieldwork of the population-representative GerES V was performed from 2014 to 2017. In total, 1109 blood plasma samples were analysed for 12 PFAS including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS). PFOS was quantified in all and PFOA in almost all samples, demonstrating ubiquitous exposure. The highest geometric mean concentrations measured were 2.49 ng/mL for PFOS, followed by PFOA (1.12 ng/mL) and PFHxS (0.36 ng/mL), while concentrations of other PFAS were found in much lower concentrations. The 95th percentile levels of PFOS and PFOA were 6.00 and 3.24 ng/mL, respectively. The results document a still considerable exposure of the young generation to the phased out chemicals PFOS and PFOA. The observed exposure levels vary substantially between individuals and might be due to different multiple sources. The relative contribution of various exposure parameters such as diet or the specific use of consumer products need to be further explored. Although additional investigations on the time trend of human exposure are warranted, GerES V underlines the need for an effective and sustainable regulation of PFAS as a whole. Source: © 2020 Elsevier GmbH