Person: Grummt, Tamara
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1955
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Grummt
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Tamara
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Veröffentlichung Chemicals and cell-based assays in drinking water sources in Manhiça, Mozambique(2021) Villanueva, Cristina M.; Grau-Pujol, Berta; Evlampidou, Iro; Grummt, Tamara; Kuckelkorn, JochenBackground The chemical quality of drinking water is widely unknown in low-income countries. Objective We conducted an exploratory study in Manhiça district (Mozambique) to evaluate drinking water quality using chemical analyses and cell-based assays. Methods We measured nitrate, fluoride, metals, pesticides, disinfection by-products, and industrial organochlorinated chemicals, and conducted the bioassays Ames test for mutagenicity, micronuclei assay (MN-FACS), ER-CALUX, and antiAR-CALUX in 20 water samples from protected and unprotected sources. Results Nitrate was present in all samples (median 7.5†mg/L). Manganese, cobalt, chromium, aluminium, and barium were present in 90-100% of the samples, with median values of 32, 0.6, 2.0, 61, 250†(mirco)g/l, respectively. Manganese was above 50†ÎÌg/l (EU guideline) in eight samples. Arsenic, lead, nickel, iron, and selenium median values were below the quantification limit. Antimony, cadmium, copper, mercury, zinc and silver were not present. Trihalomethanes, haloacetic acids, haloacetonitriles and haloketones were present in 5-28% samples at levelsVeröffentlichung In vitro characterization of cutaneous immunotoxicity of immortalized human keratinocytes (HaCaT) exposed to reactive and disperse textile dyes(2018) Leme, Daniela Morais; Grummt, Tamara; Sehr, AndreaSeveral synthetic dyes are used by textile industry for supplying the market of colored clothes. However, these chemicals have been associated with a variety of adverse human health effects, including textile dermatitis. Thus, there is a growing concern to identify textile dyes potentially as skin immunotoxicants. The aim of this in vitro study was to characterize the immunotoxic potential of reactive (Reactive Green 19 [RG19], Reactive Blue 2 [RB2], Reactive Black 5 [RB5]) and disperse (Disperse Red 1 [DR1]) textile dyes using a dermal cell line. For this purpose, a cell-based approach was conducted with immortalized human keratinocytes (KC) (HaCaT) using selected biomarkers of cutaneous inflammation including modulation of matrix metalloproteinases (MMP), oxidative stress such as reactive oxygen species (ROS) generation, and inflammatory cytokine profile. DR1 was the only dye able to trigger an immune response such as release of IL-12 cytokine, a potent co-stimulator of T helper 1 cell, which may be considered as a skin immunotoxicant. The reactive dyes including RB5 that were previously reported as skin sensitizers failed to induce inflammatory reactions under the conditions tested. The reactive dyes studied may pose a risk to human KC by induction of effects related to modulation of MMP-2 (RB5) and -9 (RB5 and RB2) and generation of ROS (RG19 and RB2). Thus, all these dyes need to be used with caution to avoid undesirable effects to consumers who may be exposed dermally. Quelle: https://www.tandfonline.comVeröffentlichung Rund um das Badewasser(2016) Ahrendt, Lilli; Feuerpfeil, Irmgard; Grummt, Tamara; Hummel, Annette; Szewzyk, Regine; Vigelahn, LotharWie kommt es zum typischen Hallenbadgeruch? Wie wird das Beckenwasser in Schwimmbädern gereinigt? Was ist beim Schwimmen lernen zu beachten? Gibt es Besonderheiten beim Baden in freier Natur? Schon vor dem Laufen lernen ins Wasser? All das und vieles mehr erfahren Sie in unserem Ratgeber. Quelle: https://www.umweltbundesamt.deVeröffentlichung Gesundheitsbezogene Optimierung der Aufbereitung von Badebeckenwasser(2016) Grummt, Tamara; Schmalz, Christina; Junek, Ralf; Waldmann, PetraVeröffentlichung Rund um das Trinkwasser(2016) Bartel, Hartmut; Dieter, Hermann H.; Feuerpfeil, Irmgard; Grummt, Hans-Jürgen; Grummt, Tamara; Hummel, Annette; Konietzka, Rainer; Rapp, Thomas; Rechenberg, Jörg; Schaefer, Benedikt; Vigelahn, Lothar; Deutschland. UmweltbundesamtVeröffentlichung Relevance of nano- and microplastics for freshwater ecosystems: A critical review(2019) Triebskorn, Rita; Braunbeck, Thomas; Grummt, Tamara; Ruhl, Aki SebastianThe current paper critically reviews the state-of-the-science on (1) microplastics (MP) types and particle concentrations in freshwater ecosystems, (2) MP and nanoplastics (NP) uptake and tissue translocation, (3) MP/NP-induced effects in freshwater organisms, and (4) capabilities of MP/NP to modulate the toxicity of environmental chemicals. The reviewed literature as well as new data on MP and NP concentrations in the river Elbe and on particle uptake into human cells indicate an environmental relevance of small particles in the low nano- and micrometer range higher than that of larger MP. © 2018 Elsevier B.V. All rights reserved.Veröffentlichung Schlussbericht des RiSKWa-Verbundprojekts TOX-BOX: "Gefährdungsbasiertes Risikomanagement für anthropogene Spurenstoffe zur Sicherung der Trinkwasserversorgung"(2016) Eckhardt, Alexander; Grummt, Tamara; Heinze, RitaVeröffentlichung Anthropogene Spurenstoffe(2013) Grummt, TamaraAnthropogene Spurenstoffe können aufgrund ihrer Stoffeigenschaften (Polarität, Persistenz und Mobilität) Kläranlagen passieren und bis ins Trinkwasser gelangen. Zugleich sind durch moderne analytische Messverfahren immer mehr Stoffe in immer niedrigeren Konzentrationen im Wasserkreislauf nachweisbar. Das theoretische Konzept zur Ableitung gesundheitlicher Orientierungswerte (GOW) erlaubt für Spurenstoffe, über die in der Regel eine unzureichende Datenbasis vorliegt, eine zeitnahe toxikologische Bewertung. Derzeit werden für die im GOW-Konzept genannten prioritären Wirkmechanismen (Gentoxizität, Neurotoxizität und endokrine Wirkungen) In-vitro-Testbatterien entwickelt, um eine experimentell basierte Bewertung vornehmen zu können. Am Beispiel der Humanarzneimittel lässt sich aufzeigen, dass im Falle der anthropogenen Spurenstoffe die Minimierungsstrategien nicht allein auf technischen Eliminierungsmaßnahmen in Kläranlage fokussieren müssen. Durch die Einbeziehung wichtiger Akteure (Ärzte, Apotheker, Verbraucher) ließe sich z. B. durch umweltgerechte Verschreibungspraktiken, Rücknahmesysteme und Entsorgung der Eintrag von Humanarzneistoffen in die Umwelt deutlich minimieren.
Quelle: http://link.springer.com/Veröffentlichung Effect-based evaluation of ozone treatment for removal of micropollutants and their transformation products in waste water(2021) Dopp, Elke; Pannekens, Helena; Gottschlich, Anne; Grummt, TamaraThe aim of this interdisciplinary research project in North Rhine-Westphalia (NRW), Germany, entitled "Elimination of pharmaceuticals and organic micropollutants from waste water" involved the conception of cost-effective and innovative waste-water cleaning methods. In this project in vitro assays, in vivo assays and chemical analyses were performed on three municipal waste-water treatment plants (WWTP). This publication focuses on the study of the in vitro bioassays. Cytotoxic, estrogenic, genotoxic and mutagenic effects of the original as well as enriched water samples were monitored before and after wastewater treatment steps using MTT and PAN I, ER Calux and A-YES, micronucleus and Comet assays as well as AMES test. In most cases, the measured effects were reduced after ozonation, but in general, the biological response depended upon the water composition of the WWTP, in particular on the formed by-products and concentration of micropollutants. In order to be able to assess the genotoxic and/or mutagenic potential of waste-water samples using bioassays like Ames test, Comet assay or micronucleus test an enrichment of the water sample via solid-phase extraction is recommended. This is in agreement with previous studies such as the "ToxBox"-Project of the Environmental Agency in Germany. © 2022 Informa UK LimitedVeröffentlichung Effect-related evaluation of anthropogenic trace substances-concepts for genotoxicity, neurotoxicity and endocrine effects(2018) Seiler, Thomas-Benjamin; Grummt, Tamara; Braunbeck, Thomas