Person: Kolossa-Gehring, Marike
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Kolossa-Gehring
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Marike
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Veröffentlichung New human biomonitoring methods for chemicals of concern̶the German approach to enhance relevance(2017) Fiddicke, Ulrike; Leng, Gabriele; Kolossa-Gehring, Marike; Angerer, Jürgen; Wolz, BirgitVeröffentlichung Internal exposure of young German adults to di(2-propylheptyl) phthalate (DPHP): Trends in 24-h urine samples from the German Environmental Specimen Bank 1999-2017(2019) Schmidtkunz, Christoph; Gries, Wolfgang; Kolossa-Gehring, Marike; Weber, TillDi(2-propylheptyl) phthalate (DPHP) is used as a substitute for high molecular weight phthalates like di(2-ethylhexyl) phthalate (DEHP) which were subjected to authorization under REACh in 2015. An earlier study on the time trend of exposure in human 24-h urine samples from the German Environmental Specimen Bank has revealed that metabolites of DPHP emerged in 2009 and 2012 (Schütze et al., 2015). In order to better assess a potential trend and the present state of exposure to DPHP, we now measured 180 urine samples from the German Environmental Specimen Bank, 60 per year, collected in 2011, 2014 and 2017, randomized and blinded before analysis. Together with the previously analyzed samples, data for a total of 480 samples covering 19 years from 1999 to 2017 was thus generated. We were able to show that DPHP exposure of the studied population, university students from Münster (Northwestern Germany), has remained essentially constant since 2011, after a rapid increase starting around 2009. Even so, urinary metabolite concentrations were always in the low ppb or sub-ppb range, indicating that DPHP exposure of the general population is substantially lower than for other modern plasticizers, and far below levels currently regarded as critical. DPHP is a plasticizer which is mostly used in non-sensitive applications with little probability of close contact to humans. Still, we observed how temporal trends of DPHP exposure largely follow trends of DPHP consumption in the Western European market. Our results hence demonstrate the potential of biomonitoring to sensitively detect the effects of industrial product strategy on the environment, even when biomarkers are present only at trace level. © 2019 Elsevier GmbH. All rights reserved.Veröffentlichung Discovering time-trends of the German populations exposure to contaminants by analysis of human samples of the German Environmental Specimen Bank (ESB)(2018) Göen, Thomas; Lermen, Dominik; Hildebrand, Jörg; Kolossa-Gehring, MarikeThe German Environmental Specimen Bank (ESB) is a monitoring instrument of the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety. The permanent biobank facility is run since 1981 containing environmental and human samples from Germany. All samples are collected according to standard operating procedures (SOP). An standardized annual collection of human samples at four different regional sites of the country has been established since 1997. Routine sampling is done once a year, recruiting healthy non occupationally exposed students aged 20-29 years, in an equal gender distribution. The number of participants recruited is approximately 120 students per site and year. Directly after the annual sampling process, the human samples are analyzed for selected environmental chemicals. The time-trends of lead in blood, mercury and pentachlorophenol in 24 h-urine and polychlorinated biphenyls in plasma demonstrated a decrease of exposure during the last two decades by about 40-90 percent. In parallel retrospective studies using cryo-archived samples revealed increasing time trends of emerging chemicals used as substitutes for regulated toxicants. The data demonstrates the great relevance of the ESB for the health related environmental monitoring and shows the importance of human biomonitoring as a tool in information based policy making. © 2018 Elsevier B.V. All rights reserved.Veröffentlichung Glyphosate in German adults - Time trend (2001 to 2015) of human exposure to a widely used herbicide(2017) Conrad, André; Schröter-Kermani, Christa; Hoppe, Hans-Wolfgang; Kolossa-Gehring, Marike; Pieper, Silvia; Rüther, MariaVeröffentlichung Trends in characteristics of 24-h urine samples and their relevance for human biomonitoring studies - 20 years of experience in the German Environmental Specimen Bank(2019) Lermen, Dominik; Bartel-Steinbach, Martina; Conrad, André; Gwinner, Frederik; Kolossa-Gehring, Marike; Weber, TillTo document trends in human exposure to environmental pollutants, the German Environmental Specimen Bank (ESB) has been routinely collecting and archiving 24-h urine samples from young adults at four sampling sites in Germany on an annual basis. For the purpose of normalizing measured analyte concentrations, urinary creatinine (UC), specific gravity (SG), conductivity (CON), and total urine volume (UVtot) of 24-h urine samples have also been recorded. These parameters are however susceptible to variation over time, as well as within/among participants and normalization against them can thus affect the interpretation of data regarding exposure to environmental pollutants. To evaluate the influence of normalization against these parameters, we first sought to determine variations of these parameters with regard to differences between sexes and trends over time. We analysed data from 8619 urine samples collected from 1997 to 2016. We observed an inverse relation between UVtot and UC, SG, and CON. We also found differences between sexes for UC, SG and CON, but not UVtot. UC, SG, and CON showed significant decreasing trends over time in both sexes. In contrast, a significant increase of over 30% in UVtot, independent of participant age and BMI, was revealed. This increase in UVtot and the concomitant sample dilution is likely to have an impact on measured analyte concentrations in 24-h urine samples. Hence, normalization of urinary concentrations is warranted when interpreting time trends of human exposure. Next, urinary calcium (Ca2+) concentrations of ESB participants were used to demonstrate the effects of normalization against each of the four urine parameters. From 1997 to 2016, measured Ca2+ concentrations showed a statistically significant but scientifically implausible decrease. Normalization of Ca2+ concentrations against UVtot (by calculating the total daily excretion), UC, or CON, but not SG, eliminated this decrease. Consistent with previous work, Ca2+ concentrations in urine and total daily Ca2+ excretion were higher for males than females. Normalization against UC, SG, or CON, however, attenuated this difference. Thus, to avoid misinterpretation in trend analysis and sex-specific excretion in 24-h urine samples, the calculation of the total daily excretion is recommended.Veröffentlichung Die Umweltprobenbank(2016) Conrad, André; Kolossa-Gehring, Marike; Körner, Andrea; Schröter-Kermani, Christa; Koschorreck, Jan; Mohaupt, Volker; Fliedner, Annette; Rüther, Maria; Rüdel, Heinz; Deutschland. UmweltbundesamtDie Umweltprobenbank des Bundes (UPB) ist ein Archiv. Proben des Menschen und der Umwelt lagern dort bei sehr tiefen Temperaturen. Mit den regelmäßig gesammelten Proben können wir den Zustand unserer Umwelt dokumentieren und beobachten, wie sich die Belastung durch natürliche und anthropogene (Schad)Stoffe mit der Zeit verändert. Die Proben der UPB werden so gewonnen, transportiert, aufgearbeitet und gelagert, dass ihre biologische und chemische Information auch über lange Zeiträume konstant bleibt. Auf diese Weise machen es Umweltprobenbankenmöglich, dass wir aktuelle Proben mit Archivmaterial vergleichen können, das vor Jahrzehnten gesammelt und eingelagert wurde.Quelle: https://www.umweltbundesamt.de