Person: Kolossa-Gehring, Marike
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Kolossa-Gehring
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Marike
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Veröffentlichung Determinants of exposure to acrylamide in European children and adults based on urinary biomarkers: results from the "European Human Biomonitoring Initiative" HBM4EU participating studies(2023) Fernández, Sandra; Poteser, Michael; Govarts, Eva; Kolossa-Gehring, Marike; Murawski, Aline; Rüther, Maria; Schmidt, Phillipp; Vogel, Nina; Weber, TillLittle is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014-2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3-18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20-45 years). Multivariable-adjusted pooled quantile regressions were employed to assess median differences ((beta) coefficients) with 95% confidence intervals (95% CI) in AAMA and GAMA ((micro)g/g creatinine) in relation to exposure determinants. Southern European studies had higher AAMA than Northern studies. In children/adolescents, we observed significant lower AA associated with high socioeconomic status (AAMA: (beta) = -9.1 (micro)g/g creatinine, 95% CI -15.8, -2.4; GAMA: (beta) = -3.4 (micro)g/g creatinine, 95% CI-4.7, - 2.2), living in rural areas (AAMA: (beta) = - 4.7 (micro)g/g creatinine, 95% CI - 8.6, - 0.8; GAMA: (beta) = - 1.1 (micro)g/g creatinine, 95% CI -1.9, -0.4) and increasing age (AAMA: (beta)= -1.9 (micro)g/g creatinine, 95% CI -2.4, -1.4; GAMA: (beta) = -0.7 (micro)g/g creatinine, 95% CI -0.8, -0.6). In adults, higher AAMA was also associated with high consumption of fried potatoes whereas lower AAMA was associated with higher body-mass-index. Based on this large-scale study, several potential determinants of AA exposure were identified in children/adolescents and adults in European countries. © The Author(s) 2023Veröffentlichung Trends of exposure to acrylamide as measured by urinary biomarkers levels within the HBM4EU Biomonitoring Aligned Studies (2000-2021)(2022) Poteser, Michael; Kolossa-Gehring, Marike; Laguzzi, Federica; Schettgen, Thomas; Murawski, Aline; Rüther, Maria; Schmidt, Phillipp; Vogel, Nina; Weber, TillAcrylamide, a substance potentially carcinogenic in humans, represents a very prevalent contaminant in food and is also contained in tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown to induce neurotoxicity in humans. To minimize related risks for public health, it is vital to obtain data on the actual level of exposure in differently affected segments of the population. To achieve this aim, acrylamide has been added to the list of substances of concern to be investigated in the HBM4EU project, a European initiative to obtain biomonitoring data for a number of pollutants highly relevant for public health. This report summarizes the results obtained for acrylamide, with a focus on time-trends and recent exposure levels, obtained by HBM4EU as well as by associated studies in a total of seven European countries. Mean biomarker levels were compared by sampling year and time-trends were analyzed using linear regression models and an adequate statistical test. An increasing trend of acrylamide biomarker concentrations was found in children for the years 2014-2017, while in adults an overall increase in exposure was found to be not significant for the time period of observation (2000-2021). For smokers, represented by two studies and sampling for, over a total three years, no clear tendency was observed. In conclusion, samples from European countries indicate that average acrylamide exposure still exceeds suggested benchmark levels and may be of specific concern in children. More research is required to confirm trends of declining values observed in most recent years. © 2022 by the authorsVeröffentlichung Time trends of acrylamide exposure in Europe: combined analysis of published reports and current HBM4EU Studies(2022) Poteser, Michael; Hahn, Domenica; Laguzzi, Federica; Kolossa-Gehring, Marike; Schettgen, Thomas; Vogel, Nina; Weber, Till; Zimmermann, PhilippMore than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children. © 2022 by the authors