Auflistung nach Autor:in "Scherer, Max"

Gerade angezeigt 1 - 5 von 5

Deutsche Umweltstudie zur Gesundheit von Kindern und Jugendlichen, GerES 2014-2017 (GerES V)
(2019) Scherer, Max; Pluym, Nikola; Scherer, Gerhard; Analytisch-Biologisches Forschungslabor (ABF GmbH); Medizinisches Labor Bremen (MLHB); Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin (Erlangen-Nürnberg); Deutschland. Umweltbundesamt
Deutsche Umweltstudie zur Gesundheit von Kindern und Jugendlichen, GerES 2014-2017 (GerES V)
(2019) Pluym, Nikola; Scherer, Max; Scherer, Gerhard; Analytisch-Biologisches Forschungslabor (ABF GmbH); Universität (Bochum); Deutschland. Umweltbundesamt
Human Biomonitoring in urine samples from the Environmental Specimen Bank reveals a decreasing trend over time in the exposure to the fragrance chemical lysmeral from 2000 to 2018
(2020) Scherer, Max; Kolossa-Gehring, Marike; Petreanu, Wolf; Weber, Till
2-(4-tert-butylbenzyl)propionaldehyde (trade names, e.g. lysmeral or lilial) is a fragrance chemical frequently used in cosmetic products where it is labelled as Butylphenyl methylpropional. A recently developed LC-MS/MS method for the analysis of four lysmeral metabolites (tert-butylbenzoic acid (TBBA), lysmerol, lysmerylic acid, and hydroxy-lysmerylic acid) was applied to 329 urine samples from the Environmental Specimen Bank collected between 2000 and 2018. The two major metabolites TBBA and lysmerol were found in quantifiable concentrations in almost all samples in this study and correlated significantly. Hence, both analytes proved to be specific biomarkers indicating the broad exposure to lysmeral. A significant decline was found for TBBA and lysmerol for the monitored years with the most pronounced decrease from 2012 to 2015. The daily intake (DI) was used to evaluate potential health risks with respect to the derived no-effect level (DNEL) as a threshold for exposure of the general population. The median DI (1.63 (my)g/kg bw/d) and the 95th percentile (4.69 (my)g/kg bw/d) corresponded to 2.6% and 7.5% of the lowest DNEL (62.5 (my)g/kg bw/d for oral administration), respectively. Even though a decreasing trend in exposure was observed the data still calls for efforts to reduce the exposure towards lysmeral since metabolites of lysmeral were detected in nearly all samples and adverse effects cannot be excluded. Clearly, these results need to be substantiated by HBM campaigns in population representative samples like the German Environmental Survey in adults (GerES VI) to provide more robust data for the adult population. © 2020 The Author(s)
The impact of European legislation on the reduction of environmental tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany
(2022) Burkhardt, Therese; Scherer, Max; Scherer, Gerhard; Weber, Till; Kolossa-Gehring, Marike
Time trend of exposure to secondhand tobacco smoke and polycyclic aromatic hydrocarbons between 1995 and 2019 in Germany - Showcases for successful European legislation
(2023) Burkhardt, Therese; Scherer, Max; Kolossa-Gehring, Marike; Scherer, Gerhard; Weber, Till
Starting in 2002, regulations and legislative amendments in Germany focused on the non-smoker protection with several measures to reduce exposure to secondhand tobacco smoke (SHS). The present work aimed to evaluate the relationship between polycyclic aromatic hydrocarbons (PAHs) and SHS exposure and to determine to which extent enforced non-smoking regulations and smoking bans affected the exposure of the non-smoking population in Germany since their implementation in the early 2000s until today. For this purpose, cotinine and selected monohydroxylated PAHs (OH-PAHs) were analyzed by means of (UP)LC-MS/MS in 510 24-h-urine samples of the Environmental Specimen Bank collected over a time span of 24 years from 1995 to 2019. Median urinary cotinine levels were found to steadily and significantly decline by 82% from 1995 to 2019. A significant decrease of urinary 3-hydroxybenzo[a]pyrene (19%), 1-OH-pyrene (39%), 1-naphthol (66%), 1-(17%), 2-(25%), and 3-OH-phenanthrene (22%) was also observed throughout the same time span. The decline in urinary levels of cotinine and several OH-PAHs can most likely be attributed to smoking bans and regulations limiting SHS and PAH exposure. This study therefore emphasizes the relevance of human biomonitoring to investigate the exposure of humans to chemicals of concern, assess the effectiveness of regulatory measures, and help policies to enforce provisions to protect public health. © 2022 The Authors