Comparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?

Berkner, SilviaBrandt, Ute2024-06-162024-06-162023https://doi.org/10.60810/openumwelt-2180https://openumwelt.de/handle/123456789/1679Information on transformation and persistence of chemical substances in the environment is important for hazard and risk assessment within a regulatory context or as a decision criterion in a safe and sustainable by design framework. Half-lives for human and veterinary medicinal products available from marketing authorization applications were compared between soil (OECD 307) and aquatic water/sediment systems (OECD 308). The comparison shows, that there is no obvious correlation between the total system half-lives in the two different compartments and that surpassing persistence criteria is compartment-specific in 45% of the cases. © The Author(s) 20231 Onlineresource (4 pages)online resourceenghttp://rightsstatements.org/vocab/InC/1.0/PersistenzComparing pharmaceutical persistence across terrestrial and aquatic environments: do studies according to OECD 307 and OECD 308 lead to similar outcomes?Wissenschaftlicher Artikel