Schütze, AndreGries, WolfgangKolossa-Gehring, MarikeApel, PetraSchröter-Kermani, ChristaBrühning, ThomasLeng, GabrieleKoch, Holger Martin2024-06-162024-06-162014https://openumwelt.de/handle/123456789/8580The aim of this study was to investigate a possible time trend and status quo of<BR>dipropylheptylphthalate (DPHP) exposure. DPHP is used as a substitute of other high molecular weightphthalates in high temperature applications (e.g cable wires, roofing membranes, etc.). DPHP was selected inthe cooperation project between the German Federal Ministry for Environment (BMU) and the German ChemicalIndustry Association (VCI) due to its listing as High Production Volume (HPV) chemical in the European Union.The BMU-VCI project establishes new human biomonitoring methods and biomarkers for fifty emergingsubstances. 300 urine samples (24-hour voids) from the German Environmental Specimen Bank were analyzedfor three specific, secondary oxidized DPHP metabolites (with hydroxyl, oxo and carboxy modifications of thealkyl side chain). Urine samples were collected in the years 1999, 2003, 2006, 2009 and 2012, 60 samples peryear, from 30 male and 30 female volunteers (age: 21-29 years). The samples were analyzed by liquid/liquidextraction followed by GC-HRMS, which enabled us to distinguish between DPHP and Di-iso-decyl phthalate(DiDP) metabolites. The limit of quantification was between 0.15 ìg/l and 0.3 ìg/l, depending on the metabolite.All samples were blinded before analysis. DPHP metabolites were not detected in the years 1999-2006.Thereafter, detection rates increased from 3.3% in 2009 to 21.7% in 2012. As expected, mono-oxo-propylheptylphthalate (oxo-MPHP) was the most abundant metabolite, with concentrations between <LOQ and 0.96 ìg/l.The daily DPHP intake was calculated via oxo-MPHP with a maximum of 0.32 ìg/kg bodyweight/day. Ourresults show that DPHP exposure has reached the general German population. However, exposure to DPHP isconsiderably lower than for other high molecular weight phthalates. Future measurements will enable us tomonitor the development of DPHP exposure and advise risk management steps, if warranted.<BR>Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstrct Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S.12819 Vortragsfoliengraph. Darst.enghttp://rightsstatements.org/vocab/InC/1.0/Conference proceedings