Kolossa-Gehring, MarikeApel, PetraLeng, GabrieleKoch, HolgerFiddicke, Ulrike2024-06-162024-06-162015https://openumwelt.de/handle/123456789/8023The German Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) and the German Chemical Industry Association e. V. (VCI) cooperate since 2010 to increase the knowledge on the internal exposure to chemicals of the general population. Scientific coordination and HBM studies are in the responsibility of the Federal Environment Agency. Emphasis is placed on substances with either a potential health relevance or on substances to which the general population might potentially be exposed to a considerable extent. After identification of relevant chemicals by an expert panel human biomonitoring (HBM) methods are developed and first applied to about 40 non-occupationally exposed individuals. The analytical methods are cross-validated by the working group ´Analyses in biological Materials of the German Research Foundation (DFG) and published together with pilot-test results in international, peer-reviewed journals. In parallel the Human Biomonitoring Commission of the Federal Environment Agency derives toxicologically based Human Biomonitoring-values to interpret the relevance of the exposure levels observed. Up to now 29 chemicals have been chosen for method development, 10 analytical methods are finished and HBM-values for 6 substances have most recently been derived. Application of the new methods in samples from the German Environmental Specimen Bank revealed decreasing, stable or increasing time trends for the technical solvents N-ethyl-2-pyrrolidone and N-methyl-pyrrolidone and the plasticizer alternatives Hexamoll® DINCH and di-2-propylheptyl phthalate (DPHP). Exposure levels in none of the samples analyzed up to now exceeded the respective HBM-I-value. As a next step the new methods will be applied to samples from children and adolescents from the population representative 5th German Environmental Survey. Our HBM studies contribute to a realistic exposure and risk assessment for these chemicals in Germany.<BR>Quelle: http://www.ises2015.org/[15] VortragsfolienIll., Kt.enghttp://rightsstatements.org/vocab/InC/1.0/Conference proceedings