Schröter-Kermani, ChristaConrad, André2024-06-162024-06-162013https://openumwelt.de/handle/123456789/9170Background and aimsTo assess the impact of mitigation measures on the human exposure to perfluoroalkyl substances (PFAS) and to elucidate gender and other inter-individual differences, PFAS levels in human blood plasma archived in the German Environmental Specimen Bank (ESB) have been analyzed.<BR>MethodsSince the 1980s, the ESB collects, stores, and analyzes human samples. Each year i. a. blood samples from 20-29 year-olds are acquired in four German cities. Physiological parameters are analyzed for substantiating the evaluation of the internal pollutant exposure. 258 plasma samples collected from 1982 to 2010 were analyzed for perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS). ResultsAfter increasing from 1982-86, median PFOS concentrations leveled off at 20-24 ng/mL until the late 1990s. Since 2001 PFOS levels decreased to 4 ng/mL in 2010. Since the late 1980s, PFOA fluctuates between 4.8 and 6.3 ng/mL before starting to decrease in 2008. PFHxS levels increased continuously from 1 ng/mL in 1982 to 2 ng/mL in 2001. In 2010 the median PFHxS concentration was 0.9 ng/mL. PFAS levels tend to be higher in males. The overall median PFOA level in males (5.1 ng/mL) differs significantly from the median level in females (4.5 ng/mL). A similar result is observed for PFHxS (1.7 vs. 1.1 ng/mL). The median PFOS gender difference (15.5 vs. 12.4 ng/mL) is not significant (p=0.13). Bivariate analysis yielded significant correlations between PFAS levels and total protein in plasma (rank correlations: rPFOS=0.32, rPFOA=0.26, rPFHxS=0.22). No significant associations were observed between PFAS and BMI as well as triglycerides.<BR>Conclusions<BR>ESB data reflect the impact of regulatory measures on the human PFAS exposure. It allows for analyzing associations of exposure and physiological parameters that are vital for further elucidation of time-dependent inter-individual variation in PFAS exposure. AcknowledgmentsFunding by the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety is gratefully acknowledged.<BR>Quelle: http://ehp.niehs.nih.gov1 Poster, [240 KB]enghttp://rightsstatements.org/vocab/InC/1.0/Konferenzposter