Koch, Holger M.Schütze, AndreLeibold, EdgarOtter, RainerKolossa-Gehring, MarikeBrüning, Thomas2024-06-162024-06-162015https://openumwelt.de/handle/123456789/8024Hexamoll DINCH was one of the first substances selected in the BMUB-VCI cooperation project on human biomonitoring. DINCH, a "non-phthalateŁ and "non-aromaticŁ plasticizer intended to replace critical phthalates in sensitive applications has been introduced in the European market in 2002. We investigated human metabolism after oral dosage, identified specific urinary metabolites as biomarkers of exposure, and applied the new analytical method to sensitively determine these metabolites in urine samples annually collected by the German Environmental Specimen Bank. We observed the onset of exposure in 2006 (7% of the samples >LOQ) with steadily increasing metabolite levels and 98% of the samples >LOQ in 2012. Based upon metabolism/elimination and a TDI of 1 mg/kg/day, the German Human Biomionitoring Commission derived HBM values (similar to biomonitoring equivalents, BE) of 3 mg/L (sum OH- and cx-MINCH) for children and 4.5 mg/L for adults. Current 95th percentiles of urinary levels are approx. 1000-fold below these HBM values. DINCH biomonitoring is included in the ongoing German Environmental Survey (GerES5) enabling us to closely follow DINCH exposures and propose measures for reduction of exposure, if warranted. DEHTP (tere-phthalate) and DEHA/DINA (adipates) have also gained increasing importance as a phthalate substitutes and consequently been included in the BMUB-VCI project. We have already identified valuable biomarkers for DEHTP exposure. In recently collected urine samples, we could detect these DEHTP metabolites in 100% of the samples. For DEHTP and the adipates similar steps and measures are currently on the way, as described above for DINCH. As an additional substance class of interest, sunscreen agents have recently been included in the BMUB-VCI cooperation project.<BR>Quelle: http://www.ises2015.org/25 VortragsfolienIll., graph. Darst.enghttp://rightsstatements.org/vocab/InC/1.0/Conference proceedings