Kolossa-Gehring, MarikeSchröter-Kermani, ChristaRüther, MariaConrad, AndréApel, Petra2024-06-162024-06-162014https://openumwelt.de/handle/123456789/8581Europeans are still substantially exposed tochemicals. Toxicological and epidemiological studies<BR>have revealed several associations between exposureand health effects for numerous substances. InGermany exposure to various chemicals is well documentedby the German Environmental Survey (GerES)and the Environmental Specimen Bank CESB). Many relevantsources of exposure and chemicals of concernhave changed over time: While in the past ambient airand drinking water were particularly important, today'smain sources are nutrition, indoor air, cosmetics, andconsumer products. After identification of substancesof toxicological relevance and to which the generalpopulation might considerably be exposed new humanbiomonitoring (HBM) methods for i. a. the sensitizingagent methylenediphenyldiisocyanate (MDI), the two<BR>plasticisers Hexamoll® DI NCH®,Di-2-propylheptylphthalate CDPHP)- both substitutes for Di-2-ethylhexylphthalate (DEHP)- and parabenes have beendeveloped and-if appropriate- applied to ESB samples.While MDI and DPHP seem not to be related with ameasurable exposure of occupationally non-exposedpersons, DINCH levels increase constantly since marketingof this new substance.The relevance of thesefindings is to be assessed by derivation of toxicological<BR>Human-Biomonitoring-Values as well as by HBMstudies in the population-representative GerES V. ln vestigationof chemicals relevant today by HBM helpsto prioritize futher toxicological investigations andprovides guidance for consumer decisions and policy.However, a continuous monitoring also of well knownsubstances is essential for assessing impacts of chemicals<BR>on children. GerES and ESB are funded by theFederal Ministries for the Environment as well as Educationand Research.<BR>Quelle: Programme Book : ESBB Annual Meeting, October 21-24, 2014 / ESBB. Leipzig, 2014, S. 32-3328 VortragsfolienIll., graph. Darst. Kt.enghttp://rightsstatements.org/vocab/InC/1.0/Conference proceedings