Auflistung nach Autor:in "Schoeters, Greet"

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A pilot study on the feasibility of European harmonized Human Biomonitoring: Strategies towards a common approach, challenges and opportunities
(2015) Casteleyn, Ludwine; Dumez, Birgit; Becker, Kerstin; Den Hond, Elly; Schoeters, Greet; Castaño, Argelia; Koch, Holger Martin; Angerer, Jürgen; Esteban, Marta; Exley, Karen; Sepai, Ovnair; Bloemen, Louis; Fiddicke, Ulrike; Horvath, Milena; Knudsen, Lisbeth E.; Joas, Anke; Joas, Reinhard; Biot, Pierre; Koppen, C.; Dewolf, M.-C.; Katsonouri, Andromachi; Hadjipanayis, Adamos; Cerna, Milena; Krskova, A.; Kolossa-Gehring, Marike; Nielsen, Jeanette K.S.; Jensen, J.F.; Rudnai, Peter; Közepesy, S.; Mulcahy, M.F.R.; Mannion, R.; Gutleb, Arno C.; Fischer, M.E.; Ligocka, Danuta; Jakubowski, M.; Reis, M.Fátima; Namorado, S.; Lupsa, Ioana-Rodica; Schwedler, Gerda; Gurzau, Anca Elena
In 2004theEuropeanCommissionandMemberStatesinitiatedactivitiestowardsaharmonizedap-
proach forHumanBiomonitoringsurveysthroughoutEurope.Themainobjectivewastosustainen-
vironmental healthpolicybybuildingacoherentandsustainableframeworkandbyincreasingthe
comparability ofdataacrosscountries.Apilotstudy totestcommonguidelinesforsettingupsurveys
wasconsideredakeystepinthisprocess.Throughabottom-upapproachthatincludedallstakeholders,
a jointstudyprotocolwaselaborated.
FromSeptember2011tillFebruary2012,17Europeancountriescollecteddatafrom1844mother-
child pairsintheframeofDEMOnstrationofastudytoCoordinateandPerformHumanBiomonitoring
on aEuropeanScale(DEMOCOPHES). Mercury inhairandurinarycadmiumandcotininewereselected
as biomarkersofexposurecoveredbysufficient analyticalexperience.PhthalatemetabolitesandBi-
sphenol Ainurinewereaddedtotakeintoaccountincreasingpublicandpoliticalawarenessfor
emerging typesofcontaminantsandtotestlessadvancedmarkers/markerscoveredbylessanalytical
experience.Extensiveeffortstowardschemo-analyticalcomparabilitywereincluded.
The pilotstudyshowed thatcommonapproachescanbefoundinacontextofconsiderablediffer-
ences withrespecttoexperienceandexpertize,socio-culturalbackground,economicsituationandna-
tional priorities.ItalsoevidencedthatcomparableHumanBiomonitoringresultscanbeobtainedinsuch
context.AEuropeannetworkwasbuilt,exchanging information,expertise andexperiences,andpro-
viding trainingonallaspectsofasurvey.Akeychallengewas finding therightbalancebetweenarigid
structure allowingmaximalcomparabilityanda flexibleapproachincreasingfeasibilityandcapacity
building. NextstepsinEuropeanharmonizationinHumanBiomonitoringsurveysincludetheestab-
lishment ofajointprocessforprioritizationofsubstancestocoverandbiomarkerstodevelop,linking
biomonitoring surveyswithhealthexaminationsurveysandwithresearch,andcopingwiththediverse
implementations ofEUregulationsandinternationalguidelineswithrespecttoethicsandprivacy.
©2014ElsevierInc.Allrightsreserved.
Framework for the Collection of HBM Data in Europe to Study Spatial and Time Trends of Chemical Exposure in European Citizens
(2018) Schoeters, Greet; Gilles, L.; Govarts, Eva; Conrad, André; Vogel, Nina
Human biomonitoring harmonisation - lessons learned from COPHES and DEMOCOPHES
(2014) Kolossa-Gehring, Marike; Fiddicke, Ulrike; Schwedler, Gerda; Seiwert, Margarete; Joas, Anke; Angerer, Jürgen; Koch, Holger; Biot, Pierre; Aerts, Dominique; Casteleyn, Ludwine; Castaño, Argelia; Schoeters, Greet; Sepai, Ovnair; Knudsen, Lisbeth E.; Horvath, Milena; Bloemen, Louis; Joas, Reinhard
Introduction: A major objective of the European Environment and Health Action Plan 2004-2010 was
the EU wide comparison of the population's exposure to chemicals by human biomonitoring (HBM). This
required study harmonization. COPHES (COnsortium to Perform Human biomonitoring on a European Scale)systematically developed a harmonized approach to conduct HBM on a European scale, an essentialprerequisite to get comparable data. Results: For all main aspects of study design and conduct alternativeswere compared and discussed in a transparent decision making process that can also be applied to otherstudies. To reach acceptance of all involved partners, country specific aspects were always considered. Duringworkshops and by discussing written materials all partners brought up their comments and became familiar withall instruments for fieldwork and methods for quality assurance (e.g., fieldwork manual, questionnaires, andcheck lists). However, study preconditions such as ethics requirements or acceptance of questionnairecomponents differred between countries, giving a taste of the limits of harmonization. Finally,17 of the 27COPHES countries conducted the DEMOCOPHES survey (DEMOnstration of a study to COordinate andPerform Human biomonitoring on a European Scale) using the harmonized approach. Conclusions: Theharmonized fieldwork instruments (basic questionnaire, urine and hair sampling) turned out to be of high valuefor future HBM studies. Harmonization requires detailed preparation but not necessarily in the same depth ineach part of the project. The challenge is to determine which procedures indispensably need perfectharmonization and for which general guidelines are acceptable. Acknowledgements: We are grateful to theEuropean Commission that funded COPHES (7th Framework Program No. 244237) and co-fundedDEMOCOPHES (LIFE09 ENV/BE/000410) in addition to the Federal Environment Ministry (BMUB). We alsothank all project partners (www.eu-hbm.info).
Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstract Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S.235
Implementation of the "DEMOCOPHES" Project in Romania
(2014) Lupsa,Ioana-Rodica; Kolossa-Gehring, Marike; Gurzau, Anca Elena; Gurzau, Eugen S.; Casteleyn, Ludwine; Castaño, Argelia; Schoeters, Greet; Knudsen, Lisbeth E.; Biot, Pierre; Aerts, Dominique
PFASs: What can we learn from the European Human Biomonitoring Initiative HBM4EU
(2023) Uhl, Maria; Schoeters, Greet; Kolossa-Gehring, Marike; Govarts, Eva
Per- and polyfluoroalkyl substances (PFASs) were one of the priority substance groups selected which have been investigated under the ambitious European Joint programme HBM4EU (2017-2022). In order to answer policy relevant questions concerning exposure and health effects of PFASs in Europe several activities were developed under HBM4EU namely i) synthesis of HBM data generated in Europe prior to HBM4EU by developing new platforms, ii) development of a Quality Assurance/Quality Control Program covering 12 biomarkers of PFASs, iii) aligned and harmonized human biomonitoring studies of PFASs. In addition, some cohort studies (on mother-child exposure, occupational exposure to hexavalent chromium) were initiated, and literature researches on risk assessment of mixtures of PFAS, health effects and effect biomarkers were performed. The HBM4EU Aligned Studies have generated internal exposure reference levels for 12 PFASs in 1957 European teenagers aged 12-18 years. The results showed that serum levels of 14.3% of the teenagers exceeded 6.9 (micro)g/L PFASs, which corresponds to the EFSA guideline value for a tolerable weekly intake (TWI) of 4.4 ng/kg for some of the investigated PFASs (PFOA, PFOS, PFNA and PFHxS). In Northern and Western Europe, 24% of teenagers exceeded this level. The most relevant sources of exposure identified were drinking water and some foods (fish, eggs, offal and locally produced foods). HBM4EU occupational studies also revealed very high levels of PFASs exposure in workers (P95: 192 (micro)g/L in chrome plating facilities), highlighting the importance of monitoring PFASs exposure in specific workplaces. In addition, environmental contaminated hotspots causing high exposure to the population were identified. In conclusion, the frequent and high PFASs exposure evidenced by HBM4EU strongly suggests the need to take all possible measures to prevent further contamination of the European population, in addition to adopting remediation measures in hotspot areas, to protect human health and the environment. HBM4EU findings also support the restriction of the whole group of PFASs. Further, research and definition for additional toxicological dose-effect relationship values for more PFASs compounds is needed.
Special issue editorial: Key results of the european human biomonitoring initiative - HBM4EU
(2023) Schoeters, Greet; Kolossa-Gehring, Marike; Castaño, Argelia; Weise, Philipp