Auflistung nach Autor:in "Lermen, D."

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Experiences from the German Environmental Survey (GerES) and the German Environmental Specimen Bank (ESB)
(2014) Conrad, André; Schulz, Christine; Schröter-Kermani, Christa; Rüther, Maria; Seiwert, Margarete; Lermen, D.; Wintermeyer, Dirk; Kolossa-Gehring, Marike
Introduction & methods: The German health-related environmental monitoring program investigates
human exposures to environmental stressors and consists of the German Environmental Survey (GerES) andthe Environmental Specimen Bank (ESB). In addition to human biomonitoring (HBM) and indoor monitoring fordifferent segments of the general population, standardized interviews performed in GerES yield reference dataon exposure influencing factors. The ESB obtains and cryo-preserves i. a. HBM samples, physiologicalparameters, and self-administered questionnaire data on exposure-relevant behaviors from adults (20-29 yrs.)on a yearly basis focusing on temporal changes. Results: Children in GerES IV spent 15 h 31 min at home (4:46in other indoor environments, 3:43 outdoors) differing by socio-economic status. Exposure models indicate thetime spent at home being less important for inhalative exposures than indoor pollutant levels. The ESBdocuments how the decreasing fraction of participants with dental amalgam (1997: 83 % vs. 2013:10 %) isassociated with decreasing urinary mercury (1997: 0.6 ìg/L vs. 2013: 0.07 ìg/L). ESB data on decreasing 24 hurine volumes (1986: 1.3 L vs. 2013: 2.0 L) allows for adjusting time trends in internal exposure. Conclusions &Outlook: GerES and ESB demonstrate how exposure factors can be generated within regularly conducted177population studies. As for all participants also pollutant monitoring data are available, individual associationsbetween exposure factors and internal exposures to various contaminants can be investigated. These analysescan also account for socio-demographic differences and time trends in exposure relevant behaviors. The furtherdevelopment of both studies includes online-questionnaires and interviews on potential sources of emerging pollutants. Acknowledgements: We thank the German Ministries for the Environment (BMUB) and Research(BMBF) for funding and the Robert Koch-Institute for good cooperation in GerES.
Quelle: 24th Annual Meeting ofThe International Society of Exposure Science: Exposure Science Integration to Protect Ecological Systems,Human Well-Being, and Occupational Health; Abstrct Book ISES 2014 / International Society of Exposure Science, Cincinnati: 2014, S.176-177
The German Environmental Specimen Bank: Further Insight into Inter-individual Variation in Human Biomonitoring Data
(2015) Conrad, André; Schröter-Kermani, Christa; Rüther, Maria; Uhlig, S.; Bartel-Steinbach, M.; Lermen, D.; Goeen, T.; Kolossa-Gehring, Marike
Introduction In addition to environmental pollutant concentrations, human biomonitoring (HBM) results
are influenced by behaviors, e.g. smoking, and anatomical/physiological factors, e.g. sex and urine volume.Assessing environmental sources of pollutant levels in human samples must therefore also consider these otherinfluencing factors. Methods The German Environmental Specimen bank (ESB) regularly collects humansamples which are analyzed for a set of substances before being cryo-archived and - retrospectively -foremerging pollutants. Physiological parameters, e.g. urinary creatinine, are also quantified. Each year samplesfrom 480 adults (20-29 years) from four cities are collected. Participants report on their behaviors andanthropometrics. Results and discussion 1) Bivariate analysis yielded significant correlations between levels ofperfluorinated compounds (PFAS) and protein in plasma. No association resulted for PFAS and body-massindex.PFAS are higher in males. 2) Multivariate evaluation of Hg in urine resulted in significant associationswith dental amalgam and fish consumption, explaining more than 50% of variation. 3) Mainly due to reducedemissions, lead in blood (PbB) decreased on average from 77.5 in 1985 to 11.7 ìg/L in 2013. Smokers tend tohave higher PbB levels. PbB is also constantly higher in males. 4) Mean Cu in blood differs substantially by sex:(2013: females: 1.4 vs. males: 0.9 mg/L), with oral contraceptives as one possible reason. For urinary Cu nosuch differences are observed. Conclusions and outlook ESB data allows for analyzing associations between129
HBM data, environmental levels, physiological/anatomical parameters, and behaviors. They support furtherimprovement of HBM study designs and comparability of HBM results. Further augmenting HBM trend analysisby multivariate evaluation is warranted. Acknowledgements The ESB is funded by the Federal Ministry for theEnvironment, Nature Conservation, Building and Nuclear Safety.
In: 25th Annual Meeting: Exposures in an Evolving Environment: October 18 - 22, 2015 - Henderson, Nevada: final Abstract Book. International Societyof Exposure Science. Henderson,S.129-130
Time-trends of the German population exposure to contaminants using the part for human samples of the German Environmental Specimen Bank (ESB)
(2017) Conrad, André; Lermen, D.; Kolossa-Gehring, Marike; Hildebrand, J.; Rüther, Maria; Weber, Till