Auflistung nach Autor:in "Brack, Werner"

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Current EU research activities on combined exposure to multiple chemicals
(2018) Barouki, Robert; Brack, Werner; Kolossa-Gehring, Marike
Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures. © 2018 The Authors. Published by Elsevier Ltd.
Evaluation of anthropogenic micropollutants in drinking water: the Tox-Box approach
(2015) Kramer, Meike; Brack, Werner; Rabbow, Elke; Knauer, Martina; Glatt, Hansruedi; Baumstark-Kahn, Christa; Küster, Eberhard; Grummt, Tamara; Braunbeck, Thomas; Waldmann, Petra; Hollert, Henner
Human Biomonitoring of "new" contaminants: Sub-Project 2 - Screening of target and non-target contaminants in human blood and urine
(2016) Plaßmann, Merle; Brack, Werner; Krauss, Martin; Helmholtz-Zentrum für Umweltforschung GmbH; Deutschland. Umweltbundesamt
The development of screening methods has increased over the last years due to the possibility to search for multiple targets and suspected and so far unknown compounds. Non-target screening has mostly been restricted to water and food samples, only a few studies have shown an application to biological samples. Thus the objective of this project was to develop and apply a non-target screening method to human urine and blood samples. The method development was done by using a broad range of target analytes from various chemical groups, like aromatic amines, industrial chemicals, perfluorinated alkyl acids and UV filters. For sample preparation the QuEChERS (quick, easy, cheap, effective, rugged and safe) method was tested, samples were extracted using acetonitrile and salts for phase separation, followed by a sample clean-up using dispersive solid phase extraction. Urine samples were also directly injected into the LC-HRMS.
Quelle: Verlagsinformation